We describe here the capacity of human recombinant interleukin-1-beta (IL-1β), interferon-gamma (INF-γ), interferon-alpha (INF-α), tumor necrosis factor-alpha (INF-α), interleukin-6 (IL-6) and interleukin-2
or both. Other possible functions of adhesins include modulation of theinflammatory response, adhesin-directeddegranulationfrom mast cells and adhesin-mediated bacterialphagocytosisbyneutrophils. Bacteria use two general strategies to attach themselves to host cells: fimbrial and afimbrial adhesion (Figure...
On one hand, neutrophils play an important role in bacterial killing through mechanisms such as phagocytosis, formation of extracellular traps and production of antimicrobial effector molecules. On the other hand, the release of granule proteins can cause cell and tissue damage to the host, as well...
In summary, our data provide evidence that the mesenteric fat tissue protects the host from systemic bacterial distribution after translocation from the intestine. Phagocytosis by the fat cells is one mode of action to prevent bacterial translocation. In addition, translocalizing bacteria and bacterial ...
In addition to the intrinsic factors of BEVs, the host cell type also affects BEVs internalization. In immune phagocytic cells such as neutrophils, dendritic cells, and macrophages, the primary pathway for BEVs internalization is phagocytosis [168]. In non-phagocytic cells such as epithelial cells...
Under physiologic conditions, the brain is a microbiologically sterile site and is protected from infection by highly specialized barriers, including the hard bony skull, the tough dura mater, and the restrictive blood–brain barrier (BBB). Host defense.
Evidence suggests that neutrophils are disabled by multiple mechanisms including cleavage of phagocytic receptors by neutrophil elastase and inhibition of phagocytosis by neutrophil peptides. Complement activation is impaired and neutrophil elastase may cleave activated complement from pathogens preventing ...
[164]. Additionally, Chowdhury et al. employed genetically modifiedE. colito produce an encoded nanobody antagonist of CD47. This innovative approach enhanced tumor cell phagocytosis by macrophages, ultimately resulting in complete tumor regression. The method demonstrated promising therapeutic success ...
PDCD6 regulates lactate metabolism to modulate LC3-associated phagocytosis and antibacterial defense. Nat. Commun. 15, 10157 (2024). Article CAS PubMed PubMed Central Google Scholar Meier, K. H. U. et al. Metabolic landscape of the male mouse gut identifies different niches determined by ...
This suggests that Ggta1 deletion enhances IgG-dependent bacterial phagocytosis by neutrophils. Download: Download high-res image (1MB) Download: Download full-size image Figure 5. Loss of α-gal expression enhances IgG effector function (A) Total number of infiltrating CD11b+Ly6Ghigh neutrophils ...