Leranth.AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons.Experimental Neurology. 2008Elsworth J. D., Redmond D. E., Jr., Leranth C., Bjugstad K. B., Sladek J. R., Jr., Collier T. J., ...
We first generated three AAV vectors, expressing GDNF, IL-10, or GAD65, which have demonstrated analgesic effects in previous studies, to determine the effects on neuroprotection, neuroinflammation, and neural hyperactivity, respectively. We utilized the TF injection method to administer these alone an...
神经营养因子是一类能够促进神经细胞存活,生长和分化的蛋白质或多肽,在神经系统的发育,生长和损伤后修复等过程中发挥重要作用.它们通过与相应的受体或受体复合物结合进行信号转导,发挥其生物学效应.胶质细胞源性神经营养因子(Glial cell line-derived neurotrophic factor,GDNF)是1993年Lin等首先在大鼠胶质细胞系B49......
(MSA-P).1This marks a significant milestone in the development of AB-1005 gene therapy, an adeno-associated viral vector encoding for glial cell line-derived neurotrophic factor (AAV2-GDNF) that is delivered to th...
AAV Mediated GDNF Secretion From Retinal Glia Slows Down Retinal Degeneration in a Rat Model of Retinitis Pigmentosa. Deniz Dalkara,Kathleen D Kolstad,Karen I Guerin,Natalie V Hoffmann,Meike Visel,Ryan R Klimczak,David V Schaffer,John G Flannery. Molecular Therapy . 2011...
Wang L,Muramatsu S,Lu Y,et al.Delayed delivery of AAV-GDNF prevents nigral neurodegeneration and promotes functional recovery in a rat model of Parkinson’s disease. Gene Therapy . 2002Wang L, Muramatsu S, Lu Y, Ikeguchi K, Fujimoto K, Okada T, et al. (2002) Delayed delivery of AAV...
(2006). In contrast to AAV-mediated Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent models of retinal degeneration. Mol Ther 14: 700-709.In contrast to AAV-mediated Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent ...
Human neural progenitor cell grafts project neuritic processes along host circuitry concomitantly with AAV-5 GDNF chemotaxis in the MPTP-lesioned primate midbrain. Abstract from American Society for Neural Therapy and Repair. Cell Transplant 2010; 19: 367....
Comparison of fetal mesencephalic grafts, AAV-delivered GDNF, and both combined in an MPTP-induced nonhuman primate Parkinson's model. Mol. Ther. 21, 2160-2168. doi: 10.1038/mt.201 3.180Redmond DE Jr,Mc Entire CR,Kingsbery JP,et al.Comparison of fetal mesencephalic grafts,AAV-delivered GDNF,...