同时,研究者发现AARS1能够响应细胞内乳酸水平升高而进入细胞核,从而催化YAP和TEAD发生乳酰化修饰,增强其转录活性,促进胃癌细胞增殖。此外,AARS1还被发现是Hippo信号通路下游的一个直接靶基因,从而与YAP-TEAD乳酰化修饰形成一个正反馈调控...
5 Ju, J. et al. The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.J Clin Invest134, doi:10.1172/jci174587 (2024). 6 Zong, Z. et al. Alanyl-tRNA synth...
5 Ju, J. et al. The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.J Clin Invest134, doi:10.1172/jci174587 (2024). 6 Zong, Z. et al. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 ...
参考文献 [1] Zong Z,et al. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes totumorigenesis.Cell. 2024. [2] Ju J,et al. The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer...
[2] Ju J,et al. The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer. J Clin Invest. 2024. [3] Heyu Li. et al. AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases. Nature. 2024. ...
[2] Ju J,et al. The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer. J Clin Invest. 2024. [3] Heyu Li. et al. AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases. Nature. 2024. ...
5 Ju, J. et al. The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer. J Clin Invest 134, doi:10.1172/jci174587 (2024). 6 Zong, Z. et al. Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates ...
and ATP to catalyze protein lactylation. Among the candidate substrates, we focused on the Hippo pathway, which has a well-established role in tumorigenesis. Specifically, AARS1 was found to sense intracellular lactate and translocate into the nucleus to lactylate and activate the YAP-TEAD complex...
[2] Ju J,et al. The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer. J Clin Invest. 2024. [3] Heyu Li. et al. AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases. Nature. 2024. ...
[2] Ju J,et al. The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer. J Clin Invest. 2024. [3] Heyu Li. et al. AARS1 and AARS2 sense l-lactate to regulate cGAS as global lysine lactyltransferases. Nature. 2024. ...