SrcTrophectodermYap1The tyrosine kinase Src is highly expressed in embryonic stem cells (ESCs) and ESC-differentiated cells, however, its functional role remains obscured. Here, we constitutivelyexpressed Src in
Integrin-Src-YAP1 axisActivation of PI3K/AKT pathway is one of the most recurrent resistant mechanisms for BRAF-targeted therapy, and the combination of MAPK and PI3K/AKT inhibitors becomes one of the most promising regimens for BRAF-targeted relapsed melanoma patients. Although the potent drug ...
By bioinformatics analysis and knockdown or overexpression of DAB2, we found that DAB2 upregulated Yes-associated protein 1 (YAP1) transcriptional activity. Mechanistically, DAB2 served as a scaffold protein for integrin beta 3 (ITGB3) and SRC proto-oncogene non-receptor tyrosine kinase (SRC),...
Graphical Abstract Photobleaching coupled with mathematical modeling identifies YAP1 dynamicsRegulation of nuclear export is key determinant of YAP1 localizationSerine phosphorylation is required for YAP1 nuclear export through XPO1Nuclear YAP1 remains sensitive to actin and Src-family kinase regulation ...
Bioinformatics analysis demonstrate elevated expression and mutation of several hippo pathway modulators in ESCC cells responding to NXP900 in this study.Conclusions: NXP900 is a novel potent and selective YES1/SRC kinase inhibitor with subnanomolar IC50 against YES1. NXP900 potently inhibits YAP1 ...
MUC16 C terminal fragment activates YAP1 through Src signaling to promote gallbladder cancer growthdoi:10.1002/mog2.54Fan, KunWang, JiwenZhu, KaihuaNi, XiaojianShen, ShengGong, ZijunBo, XiaoboWang, ChangchengCheng, XiZhang, ChengMedcomm: Oncology...
Furthermore, the Src-YAP1 cascade was identified as the downstream effector mechanism by which the PRPF19/MYL9 axis promoted metastasis in CRC. Taken together, our findings highlighted that the PRPF19/MYL9 axis served as a novel mechanism in CRC metastasis, which provided an attractive ...
SRC is the first identified oncogene, and its aberrant activation has been implicated as a driving event in tumor initiation and progression. However, its role in cancer stemness regulation and the underlying regulatory mechanism are still elusive. Here, we identified a YAP1 tyrosine phosphorylation...
doi:10.1016/j.yexcr.2021.112555Xinliang JiangJunichi MaruyamaHiroaki IwasaKyoko Arimoto-MatsuzakiYutaka HataExperimental Cell Research