Objective To detect the mutations of pigment epithelium derived factor (PEDF) gene in a human malignant melanoma cell line A375. Methods A375 cells and control melanocytes obtained from circumcised prepuce were cultured, genomic DNA was extracted from these cells. All eight exons of PEDF gene ...
Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569:503-508(2019)" 关键字: A-375人恶性黑色素瘤复苏细胞保种中心;传代细胞;复苏细胞;实验细胞;科研细胞; 公司简介 上海冠导生物工程有限公司,先后从ATCC、DSMZ、ECACC、RIKEN、PromoCell、ScienCell、JCRB等国内外细胞库引进细胞2000...
Therefore, this study aimed to evaluate the potential functions of tyrosinase in the human melanoma cell line A375. The expression level of tyrosinase in A375 cells was undetectable. However, markedly increased expression level was observed in the mouse melanoma cell line B16F10 and the human ...
In addition, it is the first report demonstrating KRAS mutation in IPMN-O, thus supporting the notion that IPMN-O is not distinct from the other types of IPMN. 1668 Arginase-1, a New Immunohistochemical Marker of Hepatocytes and Hepatocellular Neoplasms BC Yan, C Gong, J Hart. University of...
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(ROS) that interact with nucleotides and, contribute to oxidative DNA damage and mutation like 8-oxoguanine (8-OHdG). All together, these alterations lead to the activation of the base excision repair (BER) system and induce local immunosuppression, lipid peroxidation, apoptosis, and oxidative ...
Among the two melanoma cell lines used in this study, A375 is the most highly malignant because it displays low time of duplication, shows the activation of multiple oncogenic pathways, and carries a high pathogenic mutation in the BRAF gene [38,39]. Therefore, we chose A375 cells to inves...
- 《Mutation Research/genetic Toxicology & Environmental Mutagenesis》 被引量: 103发表: 2005年 CYP2E1 G1532C, NQO1 Pro187Ser, and CYP1B1 Val432Leu polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck. Whether women are more susceptible to lung cancer ...
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The present study investigated the correlation between CD147 expression and Raf-MEK-ERK signaling in MM using the A375 human MM cell line, which harbors the activating mutation of BRAF. The phosphorylation of epidermal growth factor receptor (EGFR) was upregulated, and mitogen-activated protein ...