A phosphorylated Areceptor agonist providing agonist properties on the Areceptor after dephosphorylation the phosphorylated Areceptor agonist comprises a ribosyl moiety and a purine moiety and being phosphorylated at the 5鈥 -position of the ribose moiety except adenosine monophosphate (AMP), adenosine ...
近来解出的A2A腺苷受体的新结构为我们揭示了一大类重要蛋白的“小动作”,这一大类蛋白便是G蛋白偶联受体(G protein-coupled receptor, GPCR)。GPCR的工作是将信号从膜的一边传递到另一边:它们捕获信使分子,比如肾上腺素、多巴胺之类,产生构象变化,而后在胞内激活一系列信号转导级联反应。人们一直以来都不太清楚GPCR...
Adenosine A2A receptors in NAc alter cocaine seeking CE O'Neill et al 1249 Figure 2 Intra-nucleus accumbens (NAc) administration of the adenosine A2A agonist CGS 21680 blocks quinpirole-induced reinstatement. (a) An intra- NAc pretreatment of the A2A receptor agonist, CGS 21680 (2.5 ng per ...
an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation...
Jarvis MF,Becker HC(1998)Single and repeated episodes of ethanolwithdrawal increase adenosine Ai,but not A2A,receptor density in mouse brain.Brain Res 78680-88. Jarvis MF,Williams M(1989)Direct autoradiographic localization ofadenosine A2 receptors in the rat brain using the A2-selective agonist[3H...
(A2AR) is a potent anti-inflammatory receptor and deficiency of this receptor leads to the development of OA in mice. Moreover, treatment using liposomally conjugated adenosine or a specific A2AR agonist improved joint scores significantly in both rats with post-traumatic OA (PTOA) and mice ...
an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation...
Since A2Aand D2receptors are colocalized in striatopallidal neurons and have antagonistic interactions in brain, we attempted to evaluate D2agonist-induced behavioral sensitization, and its modulation by the A2Areceptor. However, instead of a motor stimulation, we consistently observed a motor depress...
We observed that treatment of activated LPL with an A2AAR receptor agonist inhibited pro-inflammatory cytokines. In addi- tion, using A2AAR-deficent mice in the H. felis infection model, we observed increased gastric inflammation and confirmed the importance of A2AAR in regulating inflammatory ...
Zhao et al, “Comparative Profile of Vasodilation by CVT-3146, a Novel A2A Receptor Agonist, & Adenosine in Conscious Dogs”, Jour. of Pharm & Experimental Therapeutics, p. 182-9. Zhao et al., “Effects of caffeine on coronary vasodilation and sinus tachycardia induced by Regadenoson, a nov...