AKAPs AKAPs are a diverse family of scaffold proteins that form multi-protein complexes, integrating 3'-5'-cyclic adenosine monophosphate (cAMP) -signaling with protein kinases, phosphatases, and other effector proteins. AKAP Historical Background Early physiology experiments illustrated that stimulation...
A-kinase anchoring proteins: protein kinase A and beyond. Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the... AS Edwards,JD Scott - 《Current Opinion in Cell Biology》 被引量: 547发表: 2000...
2) A-kinase anchoring protein 12 A激酶锚定蛋白12 1. Objective To investigate promoter CpG methylation status of A-kinase anchoring protein 12(AKAP12) in acute lymphoblastic leukemia in children and analyze the association between the methylation of AKAP12 and clinicopathological features. 目的探讨...
In this context, the cAMP-dependent protein kinase (PKA) plays a central role in regulating signaling pathways that protect the heart against ROS-induced cardiac damage. In cardiac cells, spatiotemporal regulation of PKA activity is controlled by A-kinase anchoring proteins (AKAPs). This family ...
A-kinase anchoring proteins (AKAPs) are a family of scaffolding proteins that target PKA and other signaling molecules to cellular compartments and thereby spatiotemporally define cellular signaling events. The AKAP18 family comprises AKAP18α, AKAP18β, AKAP18γ, and ...
The Scaffold Protein Muscle A-Kinase Anchoring Protein β Orchestrates Cardiac Myocyte Hypertrophic Signaling Required for the Development of Heart Failure... Kapiloff, The scaffold protein muscle A-kinase anchoring protein beta orches- trates cardiac myocyte hypertrophic signaling required for the ...
上海玉博生物科技有限公司 主要致力于“Anti-AKAP95/AKAP8(A-kinase Anchoring Protein 95) 蛋白激酶A锚定蛋白95抗体 yb-1473R”的生产销售。多年的“Anti-AKAP95/AKAP8(A-kinase Anchoring Protein 95) 蛋白激酶A锚定蛋白95抗体 yb-1473R”生产与销售的经验,与各行业新
Yotiao is an A-kinase-anchoring protein (AKAP) that recruits the cyclic AMP-dependent protein kinase (protein kinase A (PKA)) and protein phosphatase 1 to the carboxyl terminus of the IKs channel to form a molecular complex and control its phosphorylation state, crucial to the cardiac cellular...
The amendment of the interpretation of recently published size-exclusion chromatography (SEC) data for A-kinase anchoring protein (AKAP12) on Sephacryl-S400 has led to an increase in the estimated size of the supermolecular state from 840 to at least 6000 kDa. Although size-exclusion chromatogra...
Protein kinase A (PKA) and the nuclear A-kinase-anchoring protein AKAP95 have previously been shown to localize in separate compartments in interphase but associate at mitosis. We demonstrate here a role for the mitotic AKAP95-PKA complex. In HeLa cells, AKAP95 is associated with the nuclear ...