这种方法揭示了内质网驻留的孤儿P型泵P5A-ATP酶(酵母中的Spf1;人类中的ATP13A1)直接与线粒体尾锚定蛋白相互作用。由于遗传学研究已经将P5A-ATP酶(P5A-ATPase)与线粒体尾锚定蛋白错位联系起来,这些作者结合生化和结构方法来确定P5A-ATP酶的功能和机制。 3. Result 这些作者在无细胞系统中重建了膜蛋白插入细胞...
P5A-ATP酶积极地将错误插入的蛋白从内质网中移出,也代表了一种以前未知的细胞保障和质量控制机制,有助于维持内质网和线粒体稳态,这也可能解释了与P5A-ATP酶功能障碍相关的多效表型。(生物谷 Bioon.com) 参考资料: Michael J. McKenna et al.The endoplasmic reticulum P5A-ATPase is a transmembrane helix disl...
这种方法揭示了内质网驻留的孤儿P型泵P5A-ATP酶(酵母中的Spf1;人类中的ATP13A1)直接与线粒体尾锚定蛋白相互作用。 由于遗传学研究已经将P5A-ATP酶(P5A-ATPase)与线粒体尾锚定蛋白错位联系起来,这些作者结合生化和结构方法来确定P5A-ATP酶的功能和机制。相关研究结果发表在2020年9月25日的Science期刊上,论文标...
此外,研究团队发现CATP-8通过调控树突受体蛋白DMA-1水平影响线虫PVD神经元树突形态发育,暗示CATP-8不仅通过移除错误定位到ER的线粒体蛋白以维持正确的ER形态,还对维持ER正常生理功能起重要作用。该研究报道ER蛋白P5A ATPase/CATP-8行使...
Here, we found that the orphan P5A-adenosine triphosphatase (ATPase) transporter ATP13A1 (Spf1 in yeast) directly interacted with the transmembrane segment (TM) of mitochondrial tail-anchored proteins. P5A-ATPase activity mediated the extraction of mistargeted proteins from the endoplasmic reticulum ...
coli. The small intein in the Thermoplasma A-ATPase is closely related to the endonuclease containing intein in the Pyrococcus A-ATPase. Phylogenetic analyses suggest that this intein was horizontally transferred between Pyrococcus and Thermoplasma, and that the small intein has persisted in Thermo...
Oligomycin A ATPase抑制剂能有效抑制ATP合成,支持体外细胞生长与分化,是生物实验中不可或缺的工具。店内的抑制剂含有效成分高达99%,且具备低内毒素、低DNA含量的优点。此外,严格的品质控制确保了产品的稳定性和可靠性。无论您是需要进行细胞研究还是其他生物实验,店内的Oligomycin A ATPase抑制剂都能满足您的需求。
P5A-ATPases exhibit a unique structural feature of P5A-ATPases described “arm-like domain” of unknown function. • The “arm-like domain” is not essential for ATP hydrolysis by the yeast Spf1p P5A-ATPase. • Deletion of the “arm-like domain” decreases autophosphorylation. Abstract...
The head piece separated from the A-ATP synthase of Halobacterium halobium hydrolyses ATP. This A1-ATPase is inhibited by nitrate but not by other chaotropic anions. The nitrate inhibition is noncompetitive with respect to ATP, reversible, and partially protected by chloride. In contrast, ATP syn...
Important residues involved in the function of the F-ATP synthase proteolipid have been replaced during evolution in the V-proteolipid, but in some cases retained in the archaeal A-ATPase. Their possible implication in the evolution of V/F/A-ATPases is discussed. This is a preview of ...