Finally, we identified transporters essential for cell proliferation in subcutaneous tumours and found that levels of glucose and amino acids can restrain proliferation in that environment. This study establishes a framework for systematically identifying critical cellular nutrient transporters, characterizing ...
The Blood–Brain Barrier (BBB) is a highly-selective physiologic barrier responsible for maintaining cerebral homeostasis. Innovative in vitro models of the BBB are needed to provide useful insights into BBB function with CNS disorders like traumatic bra
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory ...
Protein functions in the cell, such as enzymatic activity, signaling, and transport, are driven by conformational changes between multiple states1,2,3. To understand biological processes at the molecular level, we therefore require a precise description of protein dynamics1. Pump-probe time-resolved ...
Exosomes, a kind of extracellular vesicle (EV) secreted by almost all cells, have gradually gained attention from researchers due to their crucial role in intercellular communication [6,7]. Exosomes originate from different cellular sources through the endosomal pathway, and can transport various activ...
PRDX6 is a lipid-peroxidation repair enzyme with phospholipase A2 (PLA2) activity. Inhibition of PRDX6 with a PLA2 inhibitor, Darapladib, increases lipid-peroxidation damage in the parasite and disrupts transport of hemoglobin-containing vesi- c...
关键词:小城市;绿色交通;评价方法;指标体系;慢行交通 Study on Evaluation Method and Index System of Green Transport in Small Cities Liu Guangxin (Jiangsu Institute of Urban Planning and Design) Abstract: The evaluation index system of green transport is a measure to objectively evaluate the ...
Finally, cluster K (cell morphology response) contains a significant number of genes related to cell shape and structure, as well as those related to events and processes typically associated with morphological changes in the cellular envelope (cell budding, sporulation, conjugation with cellular fusion...
An important task, therefore, is to quantify the proportion of all cell types among captured spots, so-called cellular deconvolution. Following deconvolution, all captured spots can be used to better understand intercellular functions and recover the fine-grained panorama of a heterogeneous tissue. A...
Our study identifies nanometre-scale condensates as effective cellular structures and underlines the power of dissecting the web of low-affinity interactions driving liquid–liquid phase separation in order to establish how condensation processes support cell function....