Here we review the importance of endosomal and lysosomal transport pathways in neurons, the role and regulation of motor proteins involved in those pathways, and the consequences of disrupting their normal function. View chapterExplore book Methods: Tools for studying genomes and gene functions in ...
How easy is hacking a cell network? You’d be surprised with the answer #security Tweet The impact this method might have on a more ordinary people is mostly limited to petty theft of a couple of dollars from the mobile plan: it can be achieved through sending bogus USSD commands to enab...
increased cerebrovascular permeability, which are closely associated with AD advancement. By elucidating the underlying molecular mechanisms governing BBB and cellular junction dysfunctions within the context of AD, this review offers valuable insights into the pathogenesis of AD and identifies potential therap...
capabilities beyond very low-rate one-way communication. Current systems are attempting to implement two-way, “answer-back” capability. This requires a major change in pager design, since it must now transmit signals in addition to receiving them, and the transmission distances can be quite ...
In this review, we present an integral toolkit for rAd application according to four different antitumor mechanisms (Fig3), i.e., a) direct oncolysis, b) immune activation: DCs priming CTL; synergies with cellular therapies, c) reshaping tumor dynamics and 'firing up' the TME, d) tumor ta...
(CML/AML). OS caused by excessive ROS at physiological levels is likely to affect the functions of hematopoietic stem cells, such as cell growth and self-renewal, which may contribute to defective hematopoiesis. We review herein the eminent role of ROS in the hematological niche and their ...
Further investigations are warranted to answer these questions and to verify whether a blockade of the host nucleus targeted by Mtb may be a new and valid approach of anti-TB treatment. Mtb targets the host ubiquitin system The ubiquitin system refers to a network of proteins comprising enzymes ...
To answer this question, we refer to nature and look to biology as a key source of inspiration. Here we exploit a certain biological adaptive mechanism on a micro level (i.e. on a cellular basis) and also employ a rel- evant mathematical model that presents the dynamics of cells' stable...
In recent decades, cellular automata (CA) have become popular for evaluating and forecasting urban transformation over time and space, especially in rapidly developing countries. These models enhance the understanding of urban dynamics and the complex in
In a subgroup of patients with amyotrophic lateral sclerosis (ALS)/Frontotemporal dementia (FTD), the (G4C2)-RNA repeat expansion from C9orf72 chromosome binds to the Ran-activating protein (RanGAP) at the nuclear pore, resulting in nucleocytoplasmic transport deficit and accumulation of Ran in...