The spliceosome is a large ribonucleoprotein that splices precursor messenger RNA (pre-mRNA) in the nuclei of eukaryotic cells (reviewed in refs. 1–3). It is composed of five small nuclear ribonucleoproteins (snRNPs) and numerous non-snRNP proteins. Each snRNP consists of a small nuclear RNA ...
The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative...
The Myzozoa, which includes Apicomplexa, Chromerida, Perkinsozoa, and Dinoflagellates, consists of obligate intracellular parasites and predators that feed through cellular vampirism. These organisms are of significant interest due to their impact on ecological systems and human health, especially given ...
The spliceosome is a large ribonucleoprotein that splices precursor messenger RNA (pre-mRNA) in the nuclei of eukaryotic cells (reviewed in refs. 1–3). It is composed of five small nuclear ribonucleoproteins (snRNPs) and numerous non-snRNP proteins. Each snRNP consists of a small nuclear RNA ...
U1 snRNP-dependent function of TIAR in the regulation of alternative RNA processing of the human calcitonin/CGRP pre-mRNA. Mol. Cell. Biol. 23, 5959–5971 (2003). Article CAS PubMed PubMed Central Google Scholar Wagner, E. J. & Garcia-Blanco, M. A. Polypyrimidine tract binding protein...
EDA consists of the following steps. First, a covariance matrix is built from the atomic fluctuation in the trajectory. Only phosphate atoms (P) are included, because these atoms contain all the information needed for a reasonable description of the global dynamics. Upon matrix diagonalization, a...
The release of RNAP II is mediated by phosphorylation through P-TEFb that in turn is under control by the inhibitory 7SK small nuclear ribonucleoprotein (snRNP) complex. The 7SK snRNP consists of the 7SK non-coding RNA and the proteins MEPCE, LARP7, and HEXIM1/2. Biallelicloss-of-...
In mammals, the circadian clock consists of a cell-autonomous transcription-translation feedback loop that temporally regulates the expression of a large number of genes. Heterodimers of the CLOCK (or NPAS2) and BMAL1 proteins drive the expression of their own repressors, CRY (CRY1 and CRY2)...
11: U4/U6:U5 triple snRNP (Tr) from S. cerevisiae Gottschalk et al. 1999, Stevens and Abelson 1999. 12: H complex (H) assembled in vitro from human extracts (Jurica et al., 2002). A small h denotes proteins identified by only a single peptide. 13–18: Proposed complexes (T1–T6...
2. The method of claim 1, wherein the prokaryote or eukaryote is a cell, virus, bacteria, spore, fungus or small multi-cellular organism. 3. The method of claim 1, wherein the targeting moiety comprises an antibody, recombinant and purified thyrotropin (TSH), doxorubicin, α-snRNP or glyc...