We recently identified a series of tRNA(Sec)-like tRNA genes distributed across Bacteria that also encode a canonical tRNA(Sec). These tRNAs contain sequence elements generally recognized by cysteinyl-tRNA synthetase (CysRS). While some of these tRNAs contain a UCA Sec anticodon, most have a ...
Pontocerebellar Hypoplasia (PCH) is a heterogeneous group of rare neurodegenerative disorders that have a fetal onset, which mainly but not exclusively affect the pons and cerebellum. The first report of PCH dates back to 1917; however, the first classification was proposed by Peter G. Barth in ...
Solanum aculeatissimum and Solanum torvum belong to the Solanum species, and they are essential plants known for their high resistance to diseases and adverse conditions. They are frequently used as rootstocks for grafting and are often crossbred with ot
By optimizing the AAV capsid and the route of administration, therapeutic efficacy in various target tissues was achieved, including liver, heart, skeletal muscle and brain. This study demonstrates the feasibility of developing a toolbox of AAV-delivered nonsense suppressor tRNAs operating on premature...
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A promising approach currently under significant research involves the design of synthetic tRNAs capable of decoding stop codons [118,120]. These artificial tRNAs compete with termination factors during translation. They allow the introduction of an amino acid into the growing peptide chain, which then...
Furthermore, during starvation, lowly charged tRNAs have a role in the “transcriptional attenuation control” mechanism, found in bacterial amino acid biosynthesis operons (Elf and Ehrenberg, 2005). This control mechanism relies on the competition between ribosomes translating at the leader cistron ...
aFor her strong intellect and winning character, I strongly recommend Fuhai for admittance at your distinguished university. I am convinced that in pursuing graduate studies she will continue to display the qualities which have made her an exemplary undergraduate. 为她强的智力和赢取的个性,我强烈推荐...
However, since spacers between rDNA subunits often 1760 contain tRNAs, it was possible to validate or invalidate one of the hypotheses by searching in sequence reads for tandems or, if any, triads of tRNAs that are characteristic of the large cluster rrnIHG (see Supplementary...
While no mutations in nuclear-encoded tRNAs have been linked to human disease as of yet, the possibility that polymorphisms in tRNA genes and their varying expression could modulate the penetrance of mutations in protein-coding genes and play a role in the genotype-phenotype relationship is ...