Margaritis. 2012. A restricted cubic spline approach to assess the association between high fat fish intake and red blood cell EPA + DHA content. Nutr. Metab. Cardiovasc. Dis. 22: 318-326.Margaritis. 2012. A restricted cubic spline approach to assess the association between high fat fish...
cubic splines是data interpolation的方法。精髓就是相邻点点(knots 是曲线必经点点的意思)之间都是三次方程（cubic polynomial ）. restricted cubic splines比cubic splines特殊的地方就是要求点点两边外侧是直线（linear)，中间是cubic splines，而且要自己，一次，二次微分都连续（continuous）。a spline wit...
A spline is a drafting tool for drawing curves. In statistics, splines are a broad class of methods for transforming variables. I first introduce the concept via linear splines and work my way to restricted cubic splines which is what I (and many others) recommend. You should be aware that...
To avoid this, restricted cubic splines are used. A restricted cubic spline is a cubic spline in which the splines are constrained to be linear in the two tails. This generally provides a better fit to the data, and also has the effect of reducing the degrees of freedom. Using a ...
A restricted cubic spline transformation of the FBG–mortality association used five predefined knots (3.9, 4.7, 5.6, 6.7 and 7.8) to evaluate the non-linear associations [10]. Subgroup analyses by sex and age, as well as various categorical, spline and linear analyses, served as sensitivity ...
Restricted cubic splines are a way of testing the hypothesis thatthe relationship is not linear or summarizing a relationship that is too non-linear to be usefully summarized by a linear relationship. Restricted cubic splines are just a transformation of an independent variable.Thus, they can be ...
each panel as an HR (95% CI) with the two-sidedPvalue for Wald’s test of interaction between treatment and NT-proBNP level from Cox’s model. No adjustment for multiple comparisons was made.aRestricted cubic spline and interactionPvalue derived from LWYY model for total HF hospitalization....
c, The functional form used to calculate the cloud response is altered from the preferred specification which uses a restricted cubic spline with four knots (black) to a restricted cubic spline using 3 knots (blue) and 5 knots (yellow) as well as a cubic polynomial (green), and non-...
In addition to randomization assignment, the primary outcome model included the following predictor variables: age (as a restricted cubic spline), sex, duration of symptoms prior to receipt of study drug, calendar time (as a restricted cubic spline), vaccination status, geographic region (Midwest,...
The shape of the association between the number of male partners in the past 12 months and UAI (modeled as the restricted cubic spline with 3 knots: 1.0, 6.0, 35.0) showed that the chance of UAI for each additional male partner increased quickly among participants who reported up to 20 ...