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Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The pathogenesis of AD involves various pathophysiological events, including the accumulation of amyloid and tau, neuro-inflammation, and ne
self-supervised pretraining, the GNN produces meaningful representations for all concepts in the KG. The pretrained model is adapted to process therapeutic tasks and predict candidate indications and contraindications of drugs across an array of diseases through ...
The mission of UN Decade of Healthy Ageing (2020–2030) is to improve the lives of older people, their families and their communities. In this paper,
Tools for predicting COVID-19 outcomes enable personalized healthcare, potentially easing the disease burden. This collaborative study by 15 institutions across Europe aimed to develop a machine learning model for predicting the risk of in-hospital mortality post-SARS-CoV-2 infection. Blood samples an...
Through TCA analysis, we found that up-regulated genes during development were enriched in cytokine production and myeloid cell homeostasis (Fig.7dand Supplementary Fig.10b). Analysis of TCA and DEG for aging suggested that genes regulating chemotaxis and migration were highly expressed, and the expr...
About ovarian aging, the visible disorder of ovary itself has been studied for quite a long time. Recently, researchers have endeavored to explore the mechanism of ovarian aging in depth, and achieved to find abundant new molecular and gene loci that play a part in reproductive senescence. More...
. MCM2 in complex with MCM7 forms a helicase that unwinds the DNA duplex during replication.16It is suggested that ATR was indispensable for regulating replication in both normal tissues and cancer cells. Concerning cancer cells suffering from replication stress, it may confer a window for ...
ON101 Promotes Wound Healing Through Regulating M1 and M2 Macrophages eFigure 2. Time to Healing in mITT Supplement 3. Data Sharing Statement 1. Edmonds M. A renaissance in diabetic foot care: new evidence-based treatments. Lancet Diabetes Endocrinol. 2018;6(11):837-838. doi:10.101...