Pettaway Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry Rodriguez-Gil, J. L., Mariaelisa Graff, Anne E. Justice, Kristin L. Young, Eirini Marouli, Xinruo Zhang, Rebecca S. Fine, Elise Lim, Victoria L. Buchanan, Kristin ...
Predicting the course of kidney disease in individuals with both type 1 and type 2 diabetes mellitus (DM) is a significant clinical and policy challenge. In several regions, DM is now the leading cause of end-stage renal disease. The aim of this study to
Web-based debugger: https://github.com/alexmojaki/birdseye Stats Non-negative matrix factorization: https://github.com/ccshao/nimfa Statsmodels: http://www.statsmodels.org/stable/index.html R formulas in python: https://github.com/pydata/patsy pyrasite: code injection into running ap...
Chronic Renal Failure –Also known as simple kidney failure, this hereditary condition is one you will want to guard against by carefully examining the ancestry of any prospective kitten you may be in the market for. Hyperthyroidism –The general litheness of the breed can be accentuated by hype...
(Fig.5i,jand Extended Data Fig.9a–c). To further assess the therapeutic potential, we cultured intestinal biopsies from active, untreated IBD with either a MEK inhibitor or a negative or positive control (Methods). MEK inhibition reduced inflammatory cytokine release to similar levels as ...
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Non-negative matrix factorization for integration of data sets https://github.com/yangzi4/iNMF omicade4: Integration of multi-omics data using co-inertia analysis https://bioconductor.org/packages/release/bioc/html/omicade4.html Integration of multi-omics data using random forests: http://bmcbi...
Genetic evidence for efficacy of targeting IL-2, IL-6 and TYK2 signalling in the prevention of type 1 diabetes: a Mendelian randomisation study Tea E. Heikkilä Emilia K. Kaiser Ville Karhunen Diabetologia(2024) Using human genetics to improve safety assessment of therapeutics ...
Cell lines included fibroblasts, immortalized B-cells, or peripheral blood mononuclear cells (PBMCs). Some studies showed that genetic mutations had a negative effect on interferon or cytokine secretions, which decreased in vitro in all cell lines (Casrouge et al., 2006; Mørk et al., 2015;...
The line chart depicts cumulative area under the curve (AUC) values (right axis) as metabolites are included in successive iterations. The metabolites ultimately selected for MetRS calculation are highlighted in red. B Individual SHAP values of the selected metabolites are ranked according to their ...