Pettaway, Lois Lamerato, Alexa Hughes Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. Amidou N'Diaye, Gary K. Chen, Cameron D. Palmer, Bing Ge, Bamidele O. Tayo, Rasika A. Mathias, Jingzhong Ding, Mike A. Nalls, ...
the high risk of developing diabetes or hyperglycemia should be emphasized and a plan for monitoring blood glucose should be developed if appropriate. Of course, an asymptomatic family member with negative variant-specific testing may still be at risk of developing more ...
We presented the results using a cross-correlation heatmap, where red indicated positive correlations, and blue indicated negative correlations. Restricted cubic spline (RCS) analysis: RCS analysis was performed to examine the dose-response relationship between biomarkers and possible mortality, adjusting...
e, Representative image of GRIA4+ cells, white arrows represent positive cells, grey represent negative, scale bar = 100 μm. In total, there were 21 images from samples taken from two individuals. f, Expression of genes associated with adipokine secretion, insulin signaling, lipid ...
(Fig.5i,jand Extended Data Fig.9a–c). To further assess the therapeutic potential, we cultured intestinal biopsies from active, untreated IBD with either a MEK inhibitor or a negative or positive control (Methods). MEK inhibition reduced inflammatory cytokine release to similar levels as ...
LHDby blood group was analyzed in 3 studies [15,24,31]. An African study [24] found a significant association between LHD and AB blood group (AB vs O: OR 4.12, 95% CI 1.81-9.4) but not A orB blood groups. A US study [15] reported ORs by blood group compared to O negative bot...
12 The presence of HTN is associated with a negative prognostic factor and has a robust association with an increased risk of eGFR loss.12,13,19 According to Kidney Disease Improving Global Outcomes (KDIGO) guidelines, the risk of progression toward ESRD of a patient with IgAN is determined...
Studies have found a pronounced decline in male effective population sizes worldwide around 3000–5000 years ago. This bottleneck was not observed for female effective population sizes, which continued to increase over time. Until now, this remarkable ge
(given by negative control probes), as implemented inminfi.βvalues withPvalues of detection greater than 0.01 were set to NA. Of note, the threshold of detection (P < 0.01) is more stringent than theP < 0.05 threshold used in the other cohorts, partly because sample coverages ...
(an integrated index of multiple neurocognitive tests withnmax = 332,050), and 10 different psychiatric disorders (n = 9,725 to 807,553) from the large-scale genome-wide association studies of European ancestry. Mediation analysis was used to assess the potential causal pathway among ...