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The light-controlled gating of ion transport across membranes is central to nature (e.g., in protein channels). Herein, inspired by channelrhodopsins, we introduce a facile non-covalent approach towards light-responsive biomimetic channelrhodopsin nanoch
However, the previously identified photo-activated ligand optovin has been shown to activate endogenous Trpa1b upon violet light stimulation in zebrafish37. The Trauner group has previously succeeded in converting a different TRP channel, TRPV1, into a photoreceptor with a synthetic photoswitch that ...
Biological ion channels are molecular gatekeepers that control transport across cell membranes. Recreating the functional principle of such systems and extending it beyond physiological ionic cargo is both scientifically exciting and technologically relevant to sensing or drug release1,2. However, fabricating...
免疫原:KLH conjugated synthetic peptide derived from human C10orf62 保质期:详见说明书 标记物:详见说明书 包装规格:0.2ml/200μg 抗原来源:Rabbit 适应物种:详见说明书 克隆性:是 标识物:详见说明书 形态:详见说明书 保存条件:Store at -20 °C ...
when combining a blue-light-gated opsin with the red calcium indicator jRGECO1a, the indicator may be photoconverted into a brighter state by optogenetic stimulation with blue light (which typically exceeds fluorescence excitation light by at least one order of magnitude) and induce changes in the...
Fig. 1: Schematic illustration of synthetic procedures and therapeutic mechanisms of LRT nanomedicine. aSchematic diagram of LDH nanosheet synthesis and the subsequent drug loading.bMechanism of antitumor immune responses against orthotopic lung tumors by TTA-Q6/RRX-001 co-delivery. (1) T-type calciu...
The channel macromolecule was a protein that formed a “gated” pore having a large internal vestibule and a smaller external one. In between the vestibules lay a narrow “selectivity filter” that allowed passage of certain ions. This filter was long enough to hold more than one ion at a ...
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