Davies PA, Wang W, Hales TG, Kirkness EF (2003) A novel class of ligand-gated ion channel is activated by Zn2 +. J Biol Chem 278:712–717P. A. Davies, W. Wang, T. G. Hales and E. F. Kirkness, A novel class of ligand-gated ion channel is activated by Zn2+, J. Biol....
Five additional sets of nAChR subunits are detected as EGs and a so-called "orphan" ligand gated ion channel (LGIC) subunit, F21A3.7, with significant similarity to the nAChR gene family, is enriched. Despite the diversity of nAChR subunits expressed in UNC-4 motor neurons and the ...
Electrostatics and the selectivity of ligand-gated ion channels Biophys. J, 75 (1998), pp. 1211-1222 View PDFView articleView in ScopusGoogle Scholar Adcock et al., 2000 C. Adcock, G.R. Smith, M.S.P. Sansom The nicotinic acetylcholine receptor: from molecular model to single channel cond...
et al. X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature 469, 428–431 (2011). 23. Yip, G. M. et al. A propofol binding site on mammalian GABAA receptors identified by photolabeling. Nat Chem Biol 9, 715–720 (2013). 24. Sauguet, L....
GRIA4 functions as a ligand-gated ion channel in the central nervous system and plays an important role in fast excitatory synaptic transmission46. Expression of GRIA4 is sufficient to alter the signaling requirements for LTP during a critical period of synapse development47, and the membrane ...
GABAARs are heteropentameric, ligand-gated ion channels permeable to chloride. GABAARs can be composed from 19 different subunits, but synaptic GABAARs are understood to be primarily assembled from 2 α(1-3), 2 β(1-3), and 1 γ2 subunits (Olsen and Sieghart, 2008, Sigel and Steinmann,...
Overall, ionChannelΩ is amenable to the study of ligand gated ion channels that are receiving less attention due to limitations in current assays. A fine control of membrane ion fluxes through the ion channels is a basic requirement for the maintenance of cellular homeostasis and it is also ...
SthK, a cyclic nucleotide-modulated ion channel from Spirochaeta thermophila, activates slowly upon cAMP increase. This is reminiscent of the slow, cAMP-induced activation reported for the hyperpolarization-activated and cyclic nucleotide-gated channel H
13. The isolated ligandgated cation channel of any one of claims 912, wherein said ligandgated cation channel is isolated from a vertebrate organism. 14. A method for identifying a component of a cationselective ion channel from a vertebrate organism, said method comprising: utilizing a library...
This invention relates to biotechnology, more particularly to one or more members of the “cys-loop” ligand-gated ion channel superfamily, which are activated by a proton and/or H+/Na+exchange proteins, and methods of using the same. ...