A Ligand-Gated Ion Channel is defined as a large receptor composed of multiple subunits that forms a channel allowing the passage of ions such as Na+, K+, Ca++, or Cl-. When activated, these channels can change the membrane potential by depolarizing or hyperpolarizing it, depending on the...
A new class of ligand-gated ion channel defined by P2x receptor for the extracellular ATP.Discusses the definition of a new family of ligand-gated ion... Valera,Soledad,Hussy,... - 《Nature》 被引量: 1319发表: 1994年 Crystal structure of the ATP-gated P2X(4) ion channel in the close...
Vandenberg RJ, Schofield PR (1994) Inhibitory ligand-gated ion channel receptors: molecular biology and pharmacology of GABA A and glycine receptors. In: Peracchia C (ed) Handbook of membrane channels: molecular and cellular physiology. Academic, San Diego, pp 317–332...
The definition and design of the validation tests were conducted according to the best practice principles (e.g. V-cycle process) and by considering and respecting guidelines, standards and regulations. The typical protocol for ion channel drug screening requires two passages performed in sequence (...
Receptor and Ion-channel Trafficking. Cell Biology of Ligand-gated and Voltage-sensitive Ion Channels (Molecular and Cellular Neurobiology Series)Moss, S. J.Henley, J.EUROPEAN JOURNAL OF NEUROLOGY
Receptor and Ion‐channel Trafficking. Cell Biology of Ligand‐gated and Voltage‐sensitive Ion Channels (Molecular and Cellular Neurobiology Series)No abstract is available for this article.doi:10.1046/j.1468-1331.2003.00507_3.xK. A. Jellinger...
The term pLGIC alludes to the two functional properties of this superfamily of receptors/ion channels: 1) ligand binding and 2) ion permeation. Cholesterol and other sterols, and various types of steroids affect both the ligand recognition ability and the ion channel functions of these proteins....