Proteoliposomes were prepared as described previously59. AqueousE. colipolar lipid extract (Avanti Polar Lipids) (30 mg ml−1) and aqueous LPS fromE. coliEH100 (Ra mutant; Sigma-Aldrich) (2 mg ml−1) were sonicated briefly for homogenization. A mixture of 20 mM Tris-HCl (...
The main components of phycobilisome are bilin-containing proteins which include phycoerythrin (PE), with the maximum absorption wavelength in the range of 565 to 575 nm, phycocyanin (PC) and allophycocyanin (AC), with a maximum absorption wavelength of 620 and 650 nm, respectively. C-phyc...
Existing studies have presented limited and disparate findings on the nexus between immune cells, plasma metabolites, and metabolic dysfunction-associated steatotic liver disease (MASLD). The aim of this study was to investigate the causal relationship b
Unit 1 The Role of Chemistry in Biology 2 Atoms and Molecules 3 The Chemistry of Water 4 Carbon: The Basis of Molecular Diversity 5 Biological Macromolecules and Lipids 6 Energy and Life Unit 2 Cell Biology 7 Cell Structure and Function ...
They found that the protonation state of the prilocaine, a hydrophobic drug when neutral but amphiphilic when protonated, had a marked effect on the absorption of the molecule into the liposome, indicating that pH during preparation could play an important role in the efficacy of the therapy. ...
In addition to synthetic and semisynthetic compounds, natural products have received much attention as prolific sources of lead compounds with therapeutic effects on various diseases. In the process of screening the bioactivities of potential candidates,
Glioblastoma (GBM) is a brain tumor with the highest level of malignancy and the worst prognosis in the central nervous system. Mitochondrial metabolism plays a vital role in the occurrence and development of cancer, which provides critical substances to
During obesity onset, excessive cellular accumulation of lipids can lead to fatty liver, which causes significant liver tissue dysfunction, and concomitant activation of macrophages, that promote the appearance of a low-grad inflammation, and thus, strongly contributing in insulin resistance and general ...
(HDL2b), a re-esterification process to recycle cholesterol, and increased anti-oxidant capabilities to negate oxidative damage from peroxidation70. Although, it is unclear if the dysregulation of lipids during spaceflight would interfere with lipid utilisation during torpor, or whether lipid utilisation...
Fig. 1: Brief structure of clinical application of exosomes. Exosomes are produced by almost all living cells, mainly immune cells (including macrophages, NK cells, dendritic cells, T cells, B cells, etc.) and tumor cells. The cargo of exosomes can be roughly divided into proteins, lipids,...