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Structural changes in mitochondria after CCCP treatment were directly evaluated by CLEM combined with live imaging and FIB/SEM tomography (Figs4and5). To relocate the same few-micron square region of cells by fluorescence microscopy and electron microscopy, we developed a new method (Fig.4). Dur...
the escaped cells may dissipate electrons through aerobic respiration, thus decreasing the overall energy conversion efficiency (Fig.5a). To avoid this, the aerobic respiration
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Atypical tuberculin reactions were noted in some animals within a quarantine group of asymptomatic patas monkeys (Renquist and Potkay, 1979). Mild edema, erythema, and, in some cases, induration of the test site in the eyelid were noted. Reactions were noticed at 24 h and frequently subsided ...
NSCLC, the well-known immunohistochemistry (IHC) scoring system ranging between 0 and 3+ (with IHC 0-1+ defined as HER2 negative, IHC 2+ as weak to moderate and IHC 3+ as strong when staining in 10% of tumour cells), remains the most frequently used method to detect HER2 overexpression...
The groundwater feeding the spring hosted the most atypical microbiome, including many taxa known to be recalcitrant to cultivation. The core microbiome included the orders Sphingomonadales, Rhizobiales, and Caulobacterales, and the families Bradyrhizobiaceae and Moraxellaceae. A comparative genomic ana...
Finally, all participants were Black, which (although not atypical for the TB population in South African clinics31) may challenge the generalizability to other populations; thus, additional testing in other populations is required. Nevertheless, a previous population PK analysis showed that race was ...
The primary pathological characteristics of AD include the presence of age spots resulting from the accumulation of β-amyloid (Aβ) deposits outside cells, neurofibrillary tangles caused by atypical phosphorylation of tau proteins, abnormalities in synaptic function, and loss of neurons [94]. ...
factors for these relatively uncommon conditions is so sparse that they are grouped with AD based primarily on behavioural symptoms (despite divergent progression patterns). Whilst EOAD is not the focus of this review, current knowledge of microglial involvement in atypical variants will be addressed ...