d, Acid-catalysed 2-deoxyglycosylation of galactal-containing products to access disaccharide 39. Bn, benzyl; r.t., room temperature. Full size image Conclusion In conclusion, we have demonstrated the employment of chiral Rh(I) catalysis synergistically with boronic acid catalysis in site-selective...
To this purpose, we tested whether the disrupted BBB in the αSyn fibril-exposed Substantia Nigra Brain-Chip, could be restored by therapeutic agents targeting mechanisms for clearing of the accumulated αSyn protein. Recent reports of trehalose, a disaccharide approved by FDA, have shown beneficial...
The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients,A) 10-90% by weight of a melt-processable, water-soluble polymer,B) 5-85% by weight of isomalt, andC) 0-5% by weight of ...
EXAMPLE VI Vaccination with an oligomer of cellobiuronic acid against pneumococcic infections Cellobiuronic acid is a disaccharide which forms the basic structural element of the specific polysaccharide of pneumococcus of type III. The oligomer was prepared from para-aminophenyl cellobiuronic acid (PAP...
In disaccharide complexes, the second residue interacts directly with the protein only when the glycosidic linkage is 1-3 or 1-4. Studies on the interactions of PNA with a bivalent ligand provide valuable insights into the multivalency of lectins. The availability of detailed structural information ...
Several crystal forms of the apoprotein and of complexes with different carbohydrates were studied by X-ray diffraction. The structure of the apoprotein was solved at 1.12 A resolution. The interaction of the lectin with lactose, galactose, N-acetylgalactosamine and T-antigen disaccharide, Gal beta ...
chains are not directly involved in blood group specificity. Structural studies on the core region of various blood group active substances revealed six main types of carbohydrate chains carrying the ABH determinants – they are classified according to their terminaldisaccharidestructure (see Oriolet al...
Recombinant GTA (50 milliunits) was used in the preparative scale synthesis of 6 mg of the blood group A trisaccharide from the H disaccharide acceptor Fucα(1–2)Galβ-O-(CH2)7CH3. The reaction was judged to be 50% complete after 6 h at 37 °C. The reaction was left for another...
During LPS biosynthesis, a membrane-associated glycosyltransferase (LpxB) forms a tetra-acylated disaccharide that is further acylated to form the membrane anchor moiety of LPS. Here we solve the structure of a soluble and catalytically competent LpxB by X-ray crystallography. The structure reveals ...
Mutant R370H (1H11) produced preferentially 1-kestose, blastose, a disaccharide of unknown structure, neokestose (containing a fructosyl-moiety with β2–6 linkage to the glucose residue of sucrose) and 6-nystose, while variant K373R synthesized in addition 6-kestose and small amounts of ...