(b) Anterior cingulate cortex infusion of a-CTX MII also had no effect on the total number of infusions and/or cues earned by NIC and CUEonly rats. Figure 4 a-Conotoxin MII (a-CTX MII) infusion into the nucleus accumbens (NAc) shell did not depress locomotor activity in an open ...
α-Conotoxin MIISoluble tagLiquid-phase peptide synthesisHydrophobic benzyl amineDisulfide bondOxidative disulfide bond formations have been applied to soluble-tag-assisted method successfully to realize the total synthesis of 伪-conotoxin MII (4) that comprises 16 amino acid residues and possesses 2 ...
This study characterized the novel -conotoxin LtIA, which lacks this highly conserved motif but potently blocked 32 nAChRs with a 9.8 nM ICvalue. The off-rate of LtIA was rapid relative to Ser-Xaa-Pro-containing -conotoxin MII. Nevertheless, pre-block of 32 nAChRs with LtIA prevented the...
The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine recep- tors that modulate dopamine release and related behaviors. J Neurosci 23: 11045–11053. Elliott DS, Huizinga D, Menard SW (1989). Multiple Problem Youth: Delinquency, Substance Use, ...
Kulak JM, Nguyen TA, Olivera BM, McIntosh JM: α-Conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes. J Neurosci. 1997, 17: 5263-5270. CAS PubMed Google Scholar Konstantakaki M, Changeux J-P, Taly A: Docking of α-cobratoxin suggests a basal conformatio...
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Pharmacology of alpha-conotoxin MII-sensitive subtypes of nicotinic acetylcholine receptors isolated by breeding of null mutant mice. Subtypes of nicotinic acetylcholine receptors (nAChR) containing alpha6 subunits comprise 25 to 30% of the presynaptic nAChRs expressed in striatal dopamin... O Salminen,...
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M. pKa determination of histidine residues in α-conotoxin MII peptides by 1H NMR and constant pH molecular dynamics simulation. J. Phys. Chem. B 117, 2653–2661 (2013). Article CAS PubMed PubMed Central Google Scholar Ren, Y., Wong, S. M. & Lim, L. Y. Folic acid-conjugated ...
After assessing the dopamine response to single and multi-pulse stimulations, various compounds targeting nAChRs (nicotine, 500 nM; mecamylamine [MEC], 2 μM; dihydro-beta-erythroidine [DHβE], 500 nM; α-conotoxin MII [α-Ctx MII], 100 nM) were bath applied and dopamine ...