RNA velocity provides an approach for inferring cellular state transitions from single-cell RNA sequencing (scRNA-seq) data. Conventional RNA velocity models infer universal kinetics from all cells in an scRNA-seq experiment, resulting in unpredictable performance in experiments with multi-stage and/or...
Classic mitosis in a vertebrate cellTamara PotapovaGary GorbskyT. Potapova and G. Gorbsky, "Classic Mitosis in a Vertebrate Cell," ASCB Image and Video Library, VID-31, http://cellimages. ascb.org/u?/p4041coll12,233, Aug. 2007....
Cell 104, 83–93 (2001). References 22–24 describe the analysis of the RAN·GTP gradient that is formed around chromatin during mitosis, and how this gradient promotes microtubule growth around the chromosomes. Article CAS PubMed Google Scholar Clarke, P. R. & Zhang, C. Spatial and ...
CENPA保证作为m6A阅读器并在有丝分裂期间协调着丝粒稳态方面发挥的重要调控作用,为癌症的靶向治疗提供了潜在策略。该文章于9月20日发表在Cell Press旗下主刊Cell上。 该文作者首先对2种正常细胞株和5种癌细胞株的染色质相关RNA(caRNA)进行了m6A甲基化测序(MeRIP-seq),通过系统性深入分析发现cenRNA含有m6A修饰,并且在...
Viability, DNA synthesis and mitosis have been followed in the temperature sensitive Chinese hamster cell mutant K12 under permissive and non-permissive conditions. On incubation at 40°C cells retained their ability to form colonies at 33°C for 15 to 20 hours, but viability was lost gradually ...
Herpes simplex virus type 1 immediate-early protein Vmw110 inhibits progression of cells through mitosis and from G1 into S phase of the cell cycle J. Virol., 73 (1999), pp. 9456-9467 CrossrefView in ScopusGoogle Scholar 27 A.S. Lundberg, R.A. Weinberg Functional inactivation of the re...
During all three phases, the cell grows by producing proteins and cytoplasmic organelles. However, chromosomes are replicated only during the S phase. Thus, a cell grows (G1), continues to grow as it duplicates its chromosomes (S), grows more and prepares for mitosis (G2), and divides (...
During mitosis, in contrast to chromosomal DNA, ecDNA is segregated unevenly due to the absence of a centromere and thus the daughter cells contain different copy numbers of ecDNA. The cells containing high levels of these extrachromosomal elements may adapt better in some circumstances. Kristen ...
During mitosis, every cell comprises two spindle pole bodies (SPBs, functional metazoan centrosome equivalents): an old SPB, inherited from the previous mitosis, and a newly synthesized one (reviewed in ref. 9). Each SPB nucleates a small aster composed of one to three cytoplasmic microtubules10...
1. Introduction: an overview of programmed cell death (PCD) 2. Regulation of apoptosis 3. Anti-apoptotic and pro-survival pathways and processes identified in apoptotic resistant cells 4. Identification of anti-apoptotic sequences 5. Autophagy and autophagic death 6. Necrotic death 7. Alternative ...