CLEC5A is critical forL. monocytogenes-induced NETosis and ROS production.aMouse neutrophils were incubated with liveL. monocytogenes(L.M.) (MOI 0.1) for 60 min to determine killing ability.bNeutrophils were co-incubated withL. monocytogenes(MOI 3) and NBT reagent for 60 min, followed b...
aging TFs), CD38 deletion (b,Cd38−/−TFs) and rescued TFs after CD38 deletion (c, rescued TFs) in the six cell types.d,e, Visualization of CD38 deletion downregulated (d) and upregulated (e) rescued TFs in the network. The internal nodes represent TFs, with gray circular edges ind...
Treatment of human hepatocytes with AhR ligand, β-naphthoflavone, reduced expression of cholesterol metabolising genes and was accompanied by reduced secretion of cholesterol into culture media [97]. Silencing of the AhR expression in HepB3 cells by way of siRNA showed that the degree of up-...
A.K. Daly, G.P. Aithal, J.B. Leathart, R.A. Swainsbury, T.S. Dang, C.P. Day Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes Gastroenterology, 132 (1) (2007), pp. 272-281 View in ScopusGoogle Scholar [39] K. J...
[72]. LW is a well-known herbal formula that tonifies kidney yin and includes Radix Rehmanniae Preparata, Fructus Macrocarpii, Rhizoma Dioscoreae Oppositae, Poria, Rhizoma Alismatis, and Cortex Moutan Radicis. The writing avoids biased or emotional language with a clear and objective tone, ...
Epileptiforme Anfälle. Herpes simplex rccidivans. Bornstein, B. und Ser, L: 14: 1 (1954). Hypercholesteremia and Convulsive Re activity. Spiegel, E. A. and IFycis, H.: 3: 262 (1941). Pallidotomy and Pallido-Amygdalo- tomy. IFycis, 11. T.; Baird, II. IF. and Spiegel,...
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Immunohistochemical detection of amyloid plaques in the hippocampus of 15-month-old 2xAD mice treated with either MEL (c, d) or vehicle (a, b). NonAD mice did not develop plaques (E). Quantitative analysis of plaque load with ImageJ revealed significant MEL effects in both MTNR+ (p ...
The three isoforms of apolipoprotein E (APOE2, APOE3, and APOE4) only differ in two amino acid positions but exert quite different immunomodulatory effects. The underlying mechanism of such APOE isoform dependence remains enigmatic. Here we demonstrate t
Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they