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also known as ABCC1) by binding its promoter, leading to gemcitabine resistance in PDAC [65]. Depletion of ATF4 also decreases metastasis and tumor growth in breast cancer by mediating the TGF-β/SMAD and mTOR/RAC1-RHOA pathways [66]. The EWS-FLI1 fusion protein directly activates ATF4...
Becker G, Hengge-Aronis R (2001) What makes anEscherichia colipromoter sigma(S) dependent? Role of the −13/−14 nucleotide promoter positions and region 2.5 of sigma(S). Mol Microbiol 39:1153-1165 CASPubMedGoogle Scholar Beloin C, Dorman CJ (2003) An extended role for the nucleoid...
Fehrenbacher B, Schaller M, Wesselborg S, Stork B, Popelka H, Klionsky DJ, Sun K, Kusminski CCM, Scherer PEP, Humphrey SJ, Yang G, Yang P, Fazakerley DJ, Stöckli J, Yang JY, James DE, Heckmann BL, Yang X, Zhang X, Liu J, Goold R, McKinnon C, Rabbanian S, Collinge J,...
Caselli RJ, Reiman EM, Locke DEC, Hutton ML, Hentz JG, Hoffman-Snyder C, Woodruff BK, Alexander GE, Osborne D: Cognitive domain decline in healthy apolipoprotein E e4 homozygotes before the diagnosis of mild cognitive impairment. Arch Neurol. 2007, 64: 1306-1311. 10.1001/archneur.64.9.1306...
15-20 Participants with only gait decline had 2.1 to 3.6 times the risk (pooled HR, 2.24; 95% CI, 1.62-3.09) (Figure, B).15-20 Associations of gait decline with dementia risk were significant in Health ABC, InCHIANTI, and SNAC-K but not significant in BLSA, MCSA, and AGES-RS. ...
single dose on day 5, on the antioxidant Nrf-2, NFκB genes expression (A) and proteins concentrations (B) HO-1 and NQO1 proteins levels (C). ENT (sacubitril/valsartan), CP (cyclophosphamide), VAL (valsartan). Data are expressed as mean ± SD (n = 6). Multiple comparisons...
where the former identifies targeted sequences of DNA and the latter combines Cas9 protein [57]. Cas9 has a recognition lobe (REC) containing bridge helix and three helical domains, and a nuclease lobe (NUC) with a Topo domain, a HNH domain, a C-terminal domain (CTD), and a split RuvC...