The genomes of free-living bacteria are not static but, quite to the contrary, are highly dynamic entities over evolutionary time. Bacteria evolve rapidly by constantly swapping genetic material through lateral (horizontal) gene transfer. Even potentiall
Bu Fei Decoction (BFD) Cortex Mori Radicis, Milkvetch root, Rehmannia glutinosa, Radix asteris, Codonopsis pilosula,Schisandra chinensis Non-small cell lung cancer H1975, H292, and BEAS-2B cells; BALB/c nude mice DNA damage, decreasing Aapurinic/apyrimidinic endonuclease 1 expression. [22] ...
Botti, B. Pavan Cancer stem cells and nanomedicine: new opportunities to combat multidrug resistance? Drug Discov. Today, 25 (9) (2020), pp. 1651-1667 View PDFView articleView in ScopusGoogle Scholar [29] Y. Zhao, R. Carter, S. Natarajan, F.S. Varn, D.A. Compton, C. Gawad, et...
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The term ferroptosis was put forward in 2012 and has been researched exponentially over the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed cell death, which belongs to a type of necrosis and is distinguished from ap
(B) driven by the cumulative effects of moderate-effect-size variants and unique sets of small-effect genetic variants; (C) influenced by moderate-effect-size variants, unique sets of small-effect genetic variants and environmental factors (orange); or (D) driven by the high-effect-size ...
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Heterogeneous nuclear ribonucleoprotein A/B (hnRNPA/B) is one of the core members of the RNA binding protein (RBP) hnRNPs family, including four main subtypes, A0, A1, A2/B1 and A3, which share the similar structure and functions. With the advance in understanding the molecular biology of...
Abstract Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and revolutionized the paradigm of tumor treatment, while substantial patients remain unresponsive or develop resistance to ICIs as a single agent, which is traceable to cellular metabolic dysfunction. Although dysreg...