前列腺特异性膜抗原(prostatespecificmembraneantigen,PSMA)由前列腺上皮细胞分泌,在前列腺癌中高度表达,是用于前列腺癌原发及转移灶成像,治疗的理想靶点.靶向PSMA小分子抑制剂具有分子量小,组织渗透性好,体内循环半衰期短等优势,是目前前列腺癌分子影像探针的首选.其中,99mTc-HYNIC-PSMA标记方法简单,放化纯高,在初步...
The organ-specific absorbed doses, total-body absorbed doses andTc-HYNIC-PSMA effective doses of patients were calculated using OLINDA/EXM 1.1 software. Whole-body SPECT/CT images were also acquired from additional 10 prostate patients to investigate the feasibility ofTc-HYNIC-PSMA for imaging ...
The aims of this study was to estimate the biokinetics and dosimetry of 99mTc-EDDA/HYNIC-iPSMA (99mTc-labeled PSMA inhibitor) in eight healthy subjects and evaluate its usefulness as a tumor-imaging agent in eight prostate cancer patients....
目的:探讨99mTc标记前列腺特异性膜抗原(prostate specific membrane antigen,PSMA)小分子抑制剂(HYNIC-Glu-Urea-A,简称99mTc-PSMA) SPECT/CT显像探测前列腺癌原发灶和转移灶的临床价值。方法:回顾性分析69例(初诊12例、经治57例)前列腺癌患者99mTc-PSM...
低活性,因此,需要一种新的制剂,以满足该HYNIC‑PSMA的应用。 发明内容 [0006]99m 为解决上述背景技术中所提出的问题,本发明公开了一种锝[Tc]注射液制剂及 99m 其制备方法。尤其优选为用于诊断或治疗前列腺癌和/或其转移灶的锝[Tc]注射液及其 制剂工艺。
ZHANG J P, ZHANG J G, XU X P, et al. Evaluation of radiation dosimetry of 99mTc-HYNIC-PSMA and imaging in prostate cancer[J]. Sci Rep, 2020, 10(1): 4179. XU J Y, LI Y, XU X P, et al. Clinical application of 99mTcHY...
Comparing the role of 99mTc-HYNIC-PSMA-11 and 99mTc-MDP scintigraphy for the initial staging of intermediate to high-risk prostate cancer Nucl Med Commun (2023) There are more references available in the full text version of this article. ...
作为检测前列腺特异性膜抗原的过表达的放射性药物的99MTC-EDDA/HYNIC-IPSMA 本发明涉及一种新的放射性药物,其抑制前列腺特异性膜抗原(iPSMA),其含有肼基烟酰胺(HYNIC)作为在增加分子的亲脂性以结合PSMA的疏水性位点中的关键化学基团,结合HYNIC作为放射性金属99mTc的螯合剂的常规用途,其中乙二胺四乙酸(EDDA)用于完...
隔日行 99m Tc- 前列腺特异性膜抗原(prostate-specificmembrane antigen,PSMA)SPECT/CT检查。方法如下:静 脉注射约20mCi 99m Tc-PSMA,2h后进行全身平 面显像,显像仪器为DiscoveryNM/CT670(美国GE公司),配低能高分辨平行孔准直器,采集 能峰140keV,窗宽20%,矩阵256×1024,床速 15cm/min,行全身前位和后位...
A modified RNA aptamer with HER2-specific binding was conjugated to hynic and labeled with 99mTc, for potential use as a radiopharmaceutical for diagnostic imaging of ovarian cancer cells (SKOV-3) with high HER2 expression. The aptamer was radiolabeled with 99mTc by using hynic as the chelator an...