S82New Blood-Based Test, 7-Alpha-Hydroxy-4-Cholesten-3-One (7AlphaC4), for Bile Acid Malabsorption in Patients With Inflammatory Bowel Disease or Unspecified Diarrheadoi:10.14309/01.ajg.0000996072.09336.aeJane M. YangLabCorp, Weston, Florida, United States;Andrew Lehrhoff...
Novel LC-MS/MS method for assay of 7alpha- hydroxy-4-cholesten-3-one in human plasma. Evidence for a significant extrahepatic metabolism. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;856:15-9.Lovgren-Sandblom, A., et al., Novel LC-MS/MS method for assay of 7alpha- hydroxy-4...
EFFECT OF SHORT-TERM ADMINISTRATION OF CHOLESTYRAMINE AND CHENODEOXYCHOLIC ACID ON 7ALPHA-HYDROXY-4-CHOLESTEN-3-ONE CONCENTRATIONEFFECT OF SHORT-TERM ADMINISTRATION OF CHOLESTYRAMINE AND CHENODEOXYCHOLIC ACID ON 7ALPHA-HYDROXY-4-CHOLESTEN-3-ONE CONCENTRATIONThe NHS Modernisation Agency Critical Care Programme...
S674New Blood-Based Test, 7-Alpha-Hydroxy-4-Cholesten-3-One, for Bile Acid Malabsorption May Be Useful Diagnostic in Patients With Unspecified Diarrheadoi:10.14309/01.ajg.0000952336.89568.0fJane M. YangKelly ChunWolters KluwerThe American Journal of Gastroenterology...
7 alpha-hydroxy-4-cholesten-3-one (C4)Bile acid synthesisCYP7A1Biomarker7 alpha-hydroxy-4-cholesten-3-one (C4) is an oxidative enzymatic product of cholesterol metabolism via cholesterol 7 alpha-hydroxylase, an enzyme also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A...
BACKGROUND & AIMS: Patients with Crohn's disease (CD) often have bile acid diarrhea (BAD), due to bile acid malabsorption following ileal resection (IR). Bile acid malabsorption increases production of 7 alpha-hydroxy-4-cholesten-3-one (C4), a bile acid precursor. We investigated ...
Assay method for mitochondrial sterol 27-hydroxylase with 7 alpha-hydroxy-4-cholesten-3-one as a substrate in the rat liverdoi:10.1194/jlr.D200045-JLR200Yoshikazu OtaTadaaki EtoShun Ichi TanakaKazuo Chijiiwa
Wikvall: 12alpha-Hydroxylation of 7alpha-hydroxy-cholesten-3-one by a reconstituted system from rat liver microsomes. Biochem. Biophys. Res. commun. 54, 1030-1038 (1993)Bernhardsson C, Bjorkhem I, Danielsson H, Wikvall K. 12alpha-hydroxylation of 7alpha-hydroxy-4-cho- lesten-3-one by a...
Labeled cholesta-4,6-dien-3-one and 4-cholesten-3-one could be isolated from the intestinal contents 12 h after feeding [4-14C]7 alpha-hydroxy-4-cholesten-3-one to rabbits. It is proposed that cholesta-4,6-dien-3-one and 4-cholesten-3-one are formed from 7 alpha-hydroxy-4-...
Serum concentrations of 7-alpha-hydroxy-4-cholesten-3-one (7aC4), a precursor in bile acid synthesis, reflect BA homeostasis. Here we describe a method to accurately measure serum 7aC4 and evaluate the clinical utility in patients with diarrhea or constipation phenotypes.Donato, Leslie J....