S82New Blood-Based Test, 7-Alpha-Hydroxy-4-Cholesten-3-One (7AlphaC4), for Bile Acid Malabsorption in Patients With Inflammatory Bowel Disease or Unspecified Diarrheadoi:10.14309/01.ajg.0000996072.09336.aeJane M. YangLabCorp, Weston, Florida, United States;Andrew Lehrhoff...
EFFECT OF SHORT-TERM ADMINISTRATION OF CHOLESTYRAMINE AND CHENODEOXYCHOLIC ACID ON 7ALPHA-HYDROXY-4-CHOLESTEN-3-ONE CONCENTRATIONEFFECT OF SHORT-TERM ADMINISTRATION OF CHOLESTYRAMINE AND CHENODEOXYCHOLIC ACID ON 7ALPHA-HYDROXY-4-CHOLESTEN-3-ONE CONCENTRATIONdoi:10.1016/S1567-5688(08)70828-6J...
英文别名 COLESTOLONE | 50673-97-7 | 15-ketocholestene | Colestolonum | Colestolona | 3beta-Hydroxy-5alpha-cholest-8(14)-en-15-one | CHEBI:61829 | CL 274,471 | DTXSID6046212 | 5P8396T5XF | CL-274471 | 15-oxo-5alpha-cholest-8(14)-en-3beta-ol | 5alpha-cholest-8(14)-en-...
S674New Blood-Based Test, 7-Alpha-Hydroxy-4-Cholesten-3-One, for Bile Acid Malabsorption May Be Useful Diagnostic in Patients With Unspecified Diarrheadoi:10.14309/01.ajg.0000952336.89568.0fJane M. YangKelly ChunWolters KluwerThe American Journal of Gastroenterology...
7 alpha-hydroxy-4-cholesten-3-one (C4)Bile acid synthesisCYP7A1Biomarker7 alpha-hydroxy-4-cholesten-3-one (C4) is an oxidative enzymatic product of cholesterol metabolism via cholesterol 7 alpha-hydroxylase, an enzyme also known as cholesterol 7-alpha-monooxygenase or cytochrome P450 7A1 (CYP7A...
However, plasma 7alpha3one levels were significantly lower in LC than in CH and control groups (P< 0.01). While MVA levels did not correlate with the Child-Pugh score, there was a significant correlation between 7alpha3one level and Child-Pugh score (P< 0.005). The plasma 7alpha3one ...
A method for the determination of 7 alpha-hydroxy-4-cholesten-3-one in human serum has been developed. The method is based upon solid-phase (C18) extraction of serum after addition of 7-beta-hydroxy-4-cholesten-3-one as internal standard. The extract is analysed by reversed-phase HPLC ...
Assay method for mitochondrial sterol 27-hydroxylase with 7 alpha-hydroxy-4-cholesten-3-one as a substrate in the rat liverdoi:10.1194/jlr.D200045-JLR200Yoshikazu OtaTadaaki EtoShun Ichi TanakaKazuo Chijiiwa
BACKGROUND & AIMS: Patients with Crohn's disease (CD) often have bile acid diarrhea (BAD), due to bile acid malabsorption following ileal resection (IR). Bile acid malabsorption increases production of 7 alpha-hydroxy-4-cholesten-3-one (C4), a bile acid precursor. We investigated ...
Serum concentrations of 7-alpha-hydroxy-4-cholesten-3-one (7aC4), a precursor in bile acid synthesis, reflect BA homeostasis. Here we describe a method to accurately measure serum 7aC4 and evaluate the clinical utility in patients with diarrhea or constipation phenotypes.Donato, Leslie J....