(2007) Human colorectal mucosal O6-alkylguanine DNA- alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents. Gut, 56, 380-384.Lees NP, Harrison KL, Hall CN, Margison GP, Povey AC (2007) Human colorectal mucosal O6-alkylguanine DNA-alkyl...
Initial levels of azoxymethane-induced DNA methyl adducts are not predictive of tumor susceptibility in inbred mice. HPLC-fluorescence detection was also used to quantitate 06-MeGua and 7-methylguanine (7-MeGua), and to generate standard curves. At 6 h, both O6-... A Papanikolaou,RC Shank,...
Results : Levels of all of four markers were found to have decreased by 19–54% after smoking cessation. Urinary cotinine, 1-OHP, 2-NP and 7-MeG levels were found to have significantly decreased after smoking cessation. There were positive correlations between cotinine and three urinary PAH ...
This report indicates that the K1A8 antibody will serve to quantify DNA alkylation in human populations exposed to low levels of methylating carcinogens. 展开 关键词: GLYCOCONJUGATES CELL ADHESION METASTASIS LECTINS RAT COLON ADENOCARCINOMA DOI: 10.1093/carcin/10.5.927 被引量: 17 ...
The current study is the largest report of MGMT levels among newly diagnosed pediatric CNS tumors and the only study that has quantitated MGMT by both biochemical and Western immunoblot assays. Our results show a good correlation between the two methods (r = 0.66). Medulloblastoma/primitive ...
Dietary variables associated with DNA N7-methylguanine levels and O6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa. Billson HA,Harrison KL,Lees NP,et al. Carcinogenesis . 2009Billson HA; Harrison KI; Lees NP;.Dietary variables associated with DNA N7-methylguanine levels and...
Associations between smoking GST genotypes and N7-methylguanine levels in DNA extracted from bronchial lavage cells. Mutat. Res. 559, 11-18.Lewis SJ, Cherry NM, Niven RM, Barber PV, Povey AC. Associations between smoking, GST genotypes and N 7-methylguanine levels in DNA extracted from ...
Asso- ciations between smoking, GST genotypes and 7-methylguanine levels in DNA extracted from bronchial lavage cells. Mutat Res 2004;559(1-2):11-8.Lewis SJ, Cherry NM, Niven RM, Barber PV, Povey AC. Associations between smoking, GST genotypes and N7-methylguanine levels in DNA extracted ...
2013. Topographical study of O(6)- alkylguanine DNA alkyltransferase repair activity and N7- methylguanine levels in resected lung tissue. Chem Biol Interact 204:98-104.Crosbie, P.A.J.; Harrison, K.; Shah, R.; Watson, A.J.; Agius, R.; Barber, P.V.; Margison, G.P.; Povey, A...
N. 7-Methylguanine adducts in DNA are normally present at high levels and increase on aging: analysis by HPLC with electro chemical detection. Proc. Nati. Acad. Sci. USA, 85: 7467-7470, 1988.Park, J. W. and Ames, B. N. (1988) 7-Methylguanine adducts in DNA are normally present at...