VolinanserinAlthough hallucination-related HTR behavior induced by phenethylamine, ergoline, and tryptamine psychedelics appears to be 5-HT 2A R-mediated, the receptor(s) responsible for behavioral disruptive effects may differ among these three structural classes....
Previously the NMDA (N-methyl-D-aspartate) receptor (NMDAR) antagonist ketamine was shown to disrupt generation of the auditory event-related potential (ERP) mismatch negativity (MMN) and the performance of an 'AX'-type continuous performance test (AX-CPT)--measures of auditory and visual ...
The purpose of the present studies was to test the effects of combined treatment with a low dose of a highly selective 5-HT2A receptor antagonist (M100907; formerly MDL 100,907) and low doses of a SSRI using a behavioral screen in rodents (the differential-reinforcement-of low rate 72-s...
there is little information on the contribution of different 5-HT receptors in reversal learning. Thus, we investigated the effects of systemic administration of the 5-HT2Aantagonist M100907 (0, 0.01, 0.03, and 0.1 mg/
Aloyo and Harvey (2000) Antagonist binding at 5-HT2A and 5-HT2C receptors in the rabbit: high correlation with the profile for the human receptors. Eur.J.Pharmacol. 406 163 PMID: 11020478 Dudley et al (1988) Pharmacological effects of MDL 11,939: a selective, centrally acting antagonis...
(AcuteEffectsofMirtazapineonSleepContinuityandSleepArchitectureinDepressedPatientsAPilotStudy),《生物精神病学会》(SocofBiolPsych),2000年,48卷75-78;以及LandoltHP等人,《血清素-2受体与人类睡眠EFG能量图谱上选择性拮抗剂的作用》(Serotonin-2ReceptorsandHumanSleepEffectofSelectiveAntagonistonEEGPowerSpectra),《...
We evaluated the effects of the combined administration of the 5-HT6 receptor antagonist SB 271046 with clozapine and haloperidol, as well as the co-administration of SB 271046 or SB 399885 with risperidone and the 5-HT2A antagonist M100907, to overcome the deficits induced by MK-801 in the...
Cyamemazine is a 5-HT3, 5-HT2A, and 5-HT2C receptor antagonist with Ki values of 12 nM, 1.5 nM, and 75 nM, respectively. 靶点活性 5-HT3 Receptor:75 nM (Ki), 5-HT2A Receptor:1.5 nM (Ki), 5-HT2C Receptor:12 nM (Ki) 体外活性 方法:通过结合实验确定 Cyamemazine 对多种受体(...
Prolactin responses to d-fenfluramine (d-FEN) challenge (0.5 mg/kg PO) were examined after pre-treatment with and without the 5-HT2a/2c receptor antagonist amesergide in eight physically healthy male volunteers. Compared to pretreatment with placebo, pre-treatment with amesergide completely blo...
。生物精神病学学会(Soc ofBiol Psych),2000,第48卷75-78;及兰道特(Landolt HP)等人,血清素-2受体与人类睡眠选择性拮抗剂对脑电功率谱的影响(Serotonin-2 Receptors and HumanSleepEffect of Selective Antagonist on EEG Power Spectra.)。神经精神药理学(Neuropsychopharmacology),1999,第21卷(3)455-66]。 已...