Pharmacology of a new 5HT-M-receptor antagonist: ICS 205-930 (ICS)doi:10.1016/S0021-5198(19)59274-5Gunter EngelK H BuchheitP DonatschBP RichardsonJapanese Journal of Pharmacology
Here, we addressed the pharmacology and toxicology of synthetic organoselenium compounds and some naturally occurring organoselenium amino acids. The use of selenium as a tool in organic synthesis and as a pharmacological agent goes back to the middle of the nineteenth and the beginning of the twenti...
Ahtee, L., and Saarnivaara, L., 1973, The effect of narcotic analgesics on the uptake of 5-hydroxytryptamine and (-)-metaraminol by blood platelets,Br. J. Pharmacol.47:808–818. PubMedGoogle Scholar Airaksinen, M. M., Mustala, O., and Torsti, P., 1966, Effects of some biogenic a...
Receptor target: D2 dopamine antagonist, serotonin 5HT4 agonistMOA: blocks the inhibition of ACh neurons in the enteric nervous system --> increases gastric emptyingPK: oral bioavailability, crosses BBBAE: sedation, dystonic reactions (spasms), tardive dyskinesia, anxiety, gynecomastia/galactorrhea (...
Dementia is a major cause of disability and dependency among older people. If the lives of people with dementia are to be improved, research and its translation into druggable target are crucial. Ancient systems of healthcare (Ayurveda, Siddha, Unani and
The role of 5-HT2CR in this anxiogenic response was confirmed by pretreatment with the selective 5-HT2CR antagonist RS 102221, which blocked the anxiogenic effect of mCPP in wildtype C57BL/6J mice. Others have previously shown that both systemic and local (intra-amygdala) administration of ...
Molecular and behavioral pharmacology of two novel orally-active 5HT2 modulators: Potential utility as antipsychotic medications Two 5HT2C agonists with 2A antagonist/inverse agonist activity were characterized.These 5HT2 modulators demonstrated preclinical antipsychotic activity.The......
EMA401 AT2 (angiotensin) receptor antagonist Produces antinociception in mouse neuropathic pain models and inhibits capsaicin-induced calcium fluxes in human and DRGs IB-MECA Adenosine A3 receptor Efficacy of A3 receptor agonists in relief of allodynia in rodent models has been convincingly demonstrated ...
Muscarinic antagonist; used to PREVENT but not tx motion sickness Prochlorperazine, metoclopramide DA antagonist; DA blockers stop emesis; used to tx chemotherapy induced, estrogen induced and other blood borne causes of N&V Odansetron 5HT3 antagonist; 5HT3R found in area prostrena, peripheral ...
What is the mechanism of action of Bupropion? a. Reduces uptake of norepinephrine b. Reduces uptake of norepinephrine and 5-HT c. Weak inhibitor of norepinephrine and dopamine neuronal uptake d. Potent antagonist of 5-HT2, 5-HT3, and H1 histamine receptors ...