Thus, in stressed animals, an H3 receptor agonist, R-a-methylhista- mine (2 mM) decreased the field potentials in the BLA to 63.4±7.5% of the baseline values, which was not signifi- cantly different from that in control animals (66.2±9.3% of the baseline values, n ¼ 13, p40.05...
The 5-HT2A/2Creceptor agonist DOI, at a dose of 2.5 mg/kg i.p., caused widespread and large (as high as 60%) increments ink*for [3H]AA in brains of unanesthetized adult rats. These increments are consistent with the reported marked behavioral (5-HT2syndrome) and neuroendocrine resp...
Roth BL, Shoham M, Choudhary MS, Khan N (1997) Identification of conserved aromatic residues essential for agonist binding and second messenger production at 5- hydroxytryptamine2A receptors. Mol Pharmacol 52 (2):259-266 4. Kristiansen K, Kroeze WK, Willins DL, Gelber EI, Sa...
Preferably, the baseline intracellular response is inhibited in the presence of the inverse agonist by at least 30%, more preferably by at least 50%, and most preferably by at least 75%, as compared with the baseline response in the absence of the inverse agonist. The term “pharmaceutical ...