VERWENDUNG VON 5HT1A REZEPTOR ANTAGONISTEN ZUR VORBEUGUNG UND/ODER BEHANDLUNG VON EPILEPSIEA method of preventing and/or treating epileptic seizures in a mammal in need of such treatment, which comprises administration to said mammal of a therapeutic amount of a 5HT1A antagonist.JACOBS L...
said ring having three heteroatoms which are the same or different and which are selected from the group consisting of sulfur, oxygen and nitrogen atom and X is hydrogen, chlorine or bromine or fluorine atom, or a pharmaceutically acceptable acid addition salt thereof are active at the Central ...
1-(HETERO)ARYL-4-(KONDENSIERTES THIAZOL-2-YLALKYL)-PIPERAZIN DERIVATE, DEREN HERSTELLUNG UND DEREN VERWENDUNG IN DER BEHANDLUNG VON 5-HT1A-REZEPTOR VERMITT... Aryl and heteroaryl piperazine derivatives of formula (I) wherein, R1 is hydrogen, halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alko...
In 1980, buspirone was found to have anxiolytic potential. This finding initiated the development of the azapirones — highly serotonin 5-HT1Aagonists. The balance of evidence suggests that the azapirones act as partial agonists postsynaptically, but as full agonists presynaptically in the dorsal ...
N-(PIPERIDINYL-1-ALKYL)-SUBSTITUIERTE CYCLOHEXANCARBONSUREAMIDE ALS 5HT1A REZEPTOR ANTAGONISTENPCT No. PCT/GB94/01507 Sec. 371 Date Jan. 16, 1996 Sec. 102(e) Date Jan. 16, 1996 PCT Filed Jul. 12, 1994 PCT Pub. No. WO95/02592 PCT Pub. Date Jan. 26, 1995 ...
5-ht1a und 5-ht1d alpha rezeptorantagonistenA class of novel substituted-aryloxy-2-ol-3-(4-spiro-(alkanedioxy)isobenzofuranyl- and phthaloyl-piperidine)derivatives is disclosed useful as 5-HT1A and 5-HT1Dα antagonists.doi:EP0881224 A1Vincent Patrick Rocco...
Verwendung von antagonisten oder partiellen agonisten am 5-ht1a-rezeptor zur behandlung und praevention von kognitiven stoerungenThe description relates to the novel use of antagonists or partial agonists on the 5HT1a receptor to produce a medicament for the treatment and prevention of cognitive ...
N-(piperidinyl-1-alkyl)-substituierte cyclohexancarbonsureamide als 5ht1a rezeptor antagonisten Antagonist N- (piperidinyl-1-alkyl) -substituted cyclohexancarbonsureamide as 5HT1A receptordoi:DE69414855 T2Ian Anthony CliffeMark Antony AshwellTerence James Ward...
1-Alkoxy-naphtalen-2-carboxamid-Derivate mit hoher Affinitt für das 5-HT1A Rezeptor von SerotoninPharmaceutical compounds of the formulaFAIRHURST JOHNTUPPER DAVID EDWARD
BENKYL(IDENE)-LACTAM-DERIVATE, DEREN HERSTELLUNG UND VERWENDUNG ALS SELEKTIVE (ANT)AGONISTEN VON 5-HT1A- UND/ODER 5-HT1D REZEPTORENThe present invention relates to lactam derivatives of the formula wherein R, R, R, A, X, Z, n and the dashed line are defined herein, and pharmaceutical...