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PETER ALAN HUNTKEVIN JOHN MERCHANTMYRA GILLIGANALEXANDER CHARLES HUMPHRIESANGUS MURRAY MACLEODLAURA CATHERINE COOPERMONIQUE BODIL VAN NIELKEVIN WILSONJOSE LUIS CASTRO PINEIROTAMARA LADDUWAHETTY
US5728835A [2]. Preparation of 3-pyridylamines as 5-HT2 receptor antagonists for treatment of circulatory disorders[相关活性小分子]哈尔碱; 哈尔明碱; 肉叶云香碱; 去氢骆驼蓬碱 | 2-胺基-5-(4-硝基苯磺酰)-噻唑 | 血清胺盐酸盐 | 阿魏酸钠 | 盐酸硫利达嗪 | 依匹哌唑 | 利培酮 | ...
Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning. Psycho- pharmacology 169, 321e331.McDonald L.M. et al.: Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and ...
Besides their role as antipsychotics and antidepressants, many 5-HT2Aantagonists have also been widely used as anti-thrombogenic drugs62,63,64. The effects of antipsychotics are not confined to CNS and they can cause side-effects in other tissues, for e.g. eosinophilic endocarditis65, eosinophili...
Oxazolidines as 5-HT2A-antagonists 来自 百度文库 喜欢 0 阅读量: 8 申请(专利)号: US09380202 申请日期: 19990825 公开/公告号: US06462056B1 公开/公告日期: 20021008 申请(专利权)人: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG 发明人:...
NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine. J Neurosci 16: 373–379. CAS PubMed PubMed Central Google Scholar Wesierska M, Macias-Gonzalez R, Bures J (1990). Differential effect of ketamine ...
of antagonists that have an indole central aromatic core and a methyleneamino-N, N- dimethylformamidine group . Figure 1. 2. Result and Discussion 2.1. Chemistry The synthesis of a novel series of 5-HT receptor antagonists was performed in a manner as ...
ritanserin, as previously reported did not. Although some attenuation of the c-fos and hsp-70 immunoreactivity was seen with the 5-HT2 antagonists it was less pronounced than that induced by haloperidol or clozapine. In conclusion, 5-HT2 antagonists as well as antipsychotic compounds attenuate ...
Cognitive deficits, including attention disorders and deficits in executive functions, are a central feature of schizophrenia (Frith, 1987;Kay and Sevy, 1990;Braff, 1993). Phencyclidine and ketamine, noncompetitive antagonists at glutamate NMDA receptors, exacerbate positive and negative symptoms in schi...