Treatment with the demethylating agent 5-Azacytidine leads to prolonged survival for patients with myelodysplastic syndrome, and the demethylation induces upregulation of cancer-testis antigens. Cancer-testis antigens are well-known targets for immune recognition in cancer, and the immune system may ...
Antiapoptotic BCL-2 family members have been proposed as targets in myeloid malignancies, particularly MCL-1, BCL-2 and BCL-XL, and therapeutic agents for these targets are currently in preclinical or clinical development. However, there is no direct comparison of these antiapoptotic BCL-2 family ...
Collectively, these findings show that aerosolised 5-azacytidine targets the lung, effectively reprogrammes the epigenome of tumours, and is a promising approach to combine with other drugs for treating lung cancer. Similar content being viewed by others 5-Azacytidine inhaled dry powder formulation pr...
The combined data suggest that azaCyd and azadCyd follow different routes of intracellular metabolic activation and exert their cytotoxic activity via different intracellular targets. 展开 被引量: 18 年份: 1987 收藏 引用 批量引用 报错 分享
Total and nuclear SREBP-2 protein levels (top panel) and relative mRNA expression of its downstream targets (bottom panels) were analyzed by Western blotting and QPCR, respectively. P, SREBP-2 precursor. N, SREBP-2 nuclear form. C, in condition 1, HepG2 cells were incubated without (−...
Biliary tract cancer (BTC) is a highly malignant tumor, and identification of effective therapeutic targets to improve prognosis is urgently required. Onco... T Shibata,A Kokubu,M Gotoh,... - 《Gastroenterology》 被引量: 691发表: 2008年 加载更多研究...
BCL-2 family proteins as 5-azacytidine-sensitizing targets and determinants of response in myeloid malignancies. Leukemia. 2014;28(8):1657–65. CentralBogenberger JM, Kornblau SM, Pierceall WE, et al; BCL-2 family proteins as 5- Azacytidine-sensitizing targets and determinants of response in ...
5-Azacytidine and G-CSF Derepressed Chromatin Structure of PU.1 and Its Targets Cebpa and Cbfb In Myelodysplastic Syndrome (MDS) - ScienceDirectTomas Stopka MD, PhDPavel Burda *Petra Basova *Karin Vargova *Nikola Curik *Anna Jonasova MD *...
Epigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state Article Open access 26 January 2024 PAWI-2 overcomes tumor stemness and drug resistance via cell cycle arrest in integrin β3-KRAS-dependent pancreat...
Curr Cancer Drug Targets 8: 180 – 186 Campoli M, Ferrone S (2008) HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance. Oncogene 27: 5869 – 5885 Daurkin I, Eruslanov E, Vieweg J, Kusmartsev S (2010) Generation of antigen-presenting cells from tumor-...