5-Azacytidine(5-氮杂胞苷,氮胞苷,5-氮胞苷,Azacitidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486, CC486)属于胞嘧啶类似物,是DNA甲基转移酶抑制剂(DNMT抑制剂),可以嵌入DNA/RNA上,并作用DNA甲基转移酶,致使细胞中DNA甲基转移酶活性的缺失和DNA去甲基化,特异性抑制DNA甲基化。
英文名: 5-AZACYTIDINE 5-Azacytosine/Azacitidine 英文别名: 中文名: 5-AZACYTIDINE 5-氮杂胞嘧啶核苷/阿扎胞苷 中文别名: 5-AZACYTIDINE 5-氮杂胞嘧啶核苷/阿扎胞苷 CBNumber: CB94714269 分子式: C19H26N12O10 分子量: 582.48414 MOL File: Mol file ...
Solubility: ≥ 2.08 mg/mL (8.52 mM); Clear solution 参考文献 [1].Christman JK. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene. 2002 Aug 12;21(35):5483-95.Content Brief ...
of Decitabine as a therapeutic agent for cancers in which epigenetic silencing of critical regulatory genes has occurred. Here, the current status of our understanding of the mechanism(s) by which 5-azacytosine residues in DNA inhibit DNA methylation is reviewed with an emphasis on the ...
Two nucleoside analogs of cytosine, 5-azacytidine and 5-azadeoxycytidine, which seem to have such value because of their capabilities to affect both the stability and the methylation patterns of the nucleic acids into which they are incorporated, were tested for their ability to inhibit the ...
5- Azacytosine (1) was bis-silylated with HMDS in the presence of (NH4)SO4 to furnish trimethylsilylated azacytosine (2) in greater than 90% yield. Coupling of silylated azacytosine 2 with 1,2,3,5-tetra-O-acetyl-b-Dribofuranose (3) in DCM in the presence of TMS-triflate provided ...
上海玉博生物科技有限公司 主要致力于“5-Aza-2′-deoxycytidine (Decitabine,2′-Deoxy-5-azacytidine,地西他滨,5-氮杂-2'-脱氧胞嘧啶核)≥ Sigma A3656 5mg”的生产销售。多年的“5-Aza-2′-deoxycytidine (Decitabine,2′-Deoxy-5-azacytidine,地西他滨,5-氮杂-2'-脱
5-氮-2 -脱氧胞苷(5-Aza 2 -deoxycytidine, 5-Aza-CdR)是DNA甲基化转移酶1(DNA methyltransferase 1, DNMT1)抑制剂,一种脱氧胞苷类似物,可以降低癌细胞抑癌基因的高甲基化状态。 3. Methods: Human hepatoma carcinoma cell line HepG2 was treated by methylation inhibitor 5-Aza-2-deoxycytidine (Aza)....
4) 5-aza-CR 5-氮杂胞苷 1. AIM: To investigate correlation between DNA methylation alteration and hepatocellular carcinoma as well as to explore mechanisms of 5-aza-CR inhibiting hepatoma cell lines and reversed methylation. 目的:探讨DNA异常甲基化与肝细胞肝癌间的相关性及5-氮杂胞苷(5-aza-...
英文别名: 5-Azacytidine/5-Azacytosine320-67-2中文名: 中文别名: CBNumber: CB71031444 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 5-Azacytidine/5-Azacytosine320-67-2化学性质 安全信息5-Azacytidine/5-Azacytosine320-67-2性质、用途与生产工艺 5-Azacytidine/5-Aza...