Decitabine [NSC聽127716, DAC, dezocitidine, Aza聽dC, 2'-deoxy-5-azacytidine, Dacogen聶] is a deoxycytidine and cytarabine derivative with potent antileukaemic activity, originated by Pharmachemie. This antimetabolite is able to induce in vitro gene activation and cellular differentiation by a ...
相关产品:5-Fluorouracil | Gemcitabine | Decitabine | 5-Azacytidine | 5-BrdU | Cytarabine | Fludarabine | Capecitabine | GSK-3484862 | Ganciclovir | Bobcat339 hydrochloride | Adenosine | RG108 | SGI-1027 | 6-Mercaptopurine | Carmofur | 6-Thioguanine | Dacarbazine | Forodesine hydrochloride | CM...
上海玉博生物科技有限公司 主要致力于“5-Aza-2′-deoxycytidine (Decitabine,2′-Deoxy-5-azacytidine,地西他滨,5-氮杂-2'-脱氧胞嘧啶核)≥ Sigma A3656 5mg”的生产销售。多年的“5-Aza-2′-deoxycytidine (Decitabine,2′-Deoxy-5-azacytidine,地西他滨,5-氮杂-2'-脱
(Decitabine) to demonstrate the correlation between loss of methylation in specific gene regions and activation of the associated genes. There is now a revived interest in the use of Decitabine as a therapeutic agent for cancers in which epigenetic silencing of critical regulatory genes has occurred...
^Cihák A (1974). "Biological effects of 5-azacytidine in eukaryotes".Oncology30(5): 405–22. PMID 4142650. ^Whitelaw E and Garrick D (2005),The Epigenome,Chapter 7,In:Mammalian Genomics, Ed: Ruvinsky A & Marshall Graves JA, CABI Publishing, Wallingford, UK,ISBN 0851999107. ...
CD34 cells were separated using positive selection, Tregs are additionally of particular interest in relation to 5-Azacytidine treatment as mouse studies has shown induced expression of the transcription factor FOXP3 on naive T cells by the 5-Azacytidine deoxyribonucleoside analog decitabine. This ...
本研究探讨5'-杂氮-2'-脱氧胞苷(5-aza-2'- deoxycytidine,5-Aza-CdR,Decitabine)对高危组骨髓增生异常综合征(MDS)细胞体外作用的机制.以人MDS- RAEB细胞株MUTZ-1细胞... 佟红艳,林茂芳 - 《中国实验血液学杂志》 被引量: 42发表: 2004年 加载更多来源...
Epigenetics in clinical practice: the examples of azacitidine and decitabine in myelodysplasia and acute myeloid leukemia Leukemia, 27 (2013), pp. 1803-1812 CrossrefView in ScopusGoogle Scholar 4 P.W. Hollenbach, A.N. Nguyen, H. Brady, M. Williams, Y. Ning, N. Richard, L. Krushel, ...
Although the antileukemic capacity of decitabine has been known for almost 40 years, its therapeutic potential in hematologic malignancies is still under intensive investigation. Multiple clinical trials have shown the promising activity of low-dose decitabine in AML, MDS, CML, and hemoglobinopathies,...
Cytosine methylation appears dominant in transcriptional repression, and inhibitors of the cytosine DNA methyltransferases, vidaza (5-azacytidine (5-Aza)) and decitabine (5-aza-2′-deoxyazacytidine) can induce in vitro re-expression of genes silenced through promoter hypermethylation (Jones and Baylin,...