制备5-氮杂胞嘧啶核苷和其衍生物的方法 Methods Preparation of 5-azacytidine and derivatives thereof一种合成诸如阿扎胞苷和地西他滨等5-氮杂胞嘧啶核苷的方法包含在磺酸催化剂存在下,使硅烷化5-氮杂胞嘧啶与经保护的化学式的D-呋喃核糖偶合. A synthetic, such as azacitidine and decitabine and other 5-aza...
上海玉博生物科技有限公司 主要致力于“5-Aza-2′-deoxycytidine (Decitabine,2′-Deoxy-5-azacytidine,地西他滨,5-氮杂-2'-脱氧胞嘧啶核)≥ Sigma A3656 5mg”的生产销售。多年的“5-Aza-2′-deoxycytidine (Decitabine,2′-Deoxy-5-azacytidine,地西他滨,5-氮杂-2'-脱
The cytidine analogs 5-azacytidine (5-AZA, azacytidine) and its deoxy derivative 5-aza-2′-deoxycytidine (5-AZA-dC, decitabine) have shown efficacy for the treatment of myelodysplastic syndromes12. Regarding the treatment of solid tumors, development of epigenetic therapies has started to regain ...
英文别名2-deoxyazacytidine | 5-Aza-2'-deoxycytidine, >=97% | 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one | 2'-desoxy-5-azacytidine | 2-Desoxy-5-azacytidine | E-7373 | MLS006010136 | NSC127716 | NSC-127716 | DECITABINE (MART.) | DECITABIN ...
Cytosine methylation appears dominant in transcriptional repression, and inhibitors of the cytosine DNA methyltransferases, vidaza (5-azacytidine (5-Aza)) and decitabine (5-aza-2′-deoxyazacytidine) can induce in vitro re-expression of genes silenced through promoter hypermethylation (Jones and Baylin,...
We also demonstrate herein that the initial RR-mediated 5-azaC conversion to decitabine is terminated through its own inhibition. In conclusion, we identify RRM2 as a novel molecular target of 5-azaC in AML. Our findings provide a basis for its more widespread clinical use eith...
Epigenetic mechanisms underlying tumorigenesis have recently received much attention as potential therapeutic targets of human cancer. We designed a pilot study to target DNA methylation and histone deacetylation through the sequential administration of
5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS-demethylation and FAS re-expression, and synergism with FAS-ligand. Blood 2012; 119: 4242-4252.Ghanim V, Herrmann H, Heller G, et al. 5-azacytidine and decitabine exert proapoptotic effects on ...
In sum, resistance to decitabine and 5-azacytidine originates from adaptive responses of the pyrimidine metabolism network; these responses can be anticipated and thus exploited.doi:10.1038/s41375-020-1003-xXiaorong GuRita TohmeBenjamin Tomlinson...
Refers to a process of obtaining 2 '- Deoxy 5 - azacytidine (Decitabine), which comprises: a) reacting a donor of Glycoside Compound of formula (i), where r is alquilcarbonilo C1 - C6, fenilcarbonilo, bencilcarbonilo replaced or not; r1 is chlorine, imidato Trichloromethyl methyl -, ...