5.UTR（Untranslated Regions）：即非翻译区，是信使RNA（mRNA）分子两端的非编码片段。5'-UTR从mRNA起...
5‘UTR，是从5'帽到起始密码子（不含）二、CDS，从起始密码子（含）到终止密码子（不含终止子），...
Each gene MODEL can encode several mRNA EXONS and represent the spliced, intronless portions of the gene. An mRNA EXON may only partially code for a protein; exactly the case where upstream or downstream untranslated regions exist. The protein coding portion of an individual EXON is represented ...
They are initiated from a second distal DDX3Y promoter domain at two distinct start sites in the genes 5 untranslated region (UTR) exon-T sequence. With the aid of an EGFP-3xFLAG reporter cassette cloned downstream of DDX3Y minigenes containing exons 14 and two different exon-T extensions, ...
These mRNA isoforms have distinct 5′-UTRs but identical CDSs. We also detected a fourth, albeit rare, variant with an unannotated permutation of the 5′-UTR exons that we dubbed V4 (Figure 1A, bottom). For each 5′-UTR variant, at least 2 mRNA isoforms existed because of 2 potential ...
▲snRNA has different genes in multiple copies, which play different roles in the synthesis of other RNA classes, such as, snRNA which is part of thespliceosomesthat help in the conversion of pre-messenger RNA (hnRNA) into mRNA ...
Thus, genes with long 5UIs tend to have a high total intronic length and longer 5'UTR exons. While this tendency holds in genes with additional introns, several genes with total 5UI lengths greater than 10 kb lack any coding-region or 3'UTR introns (Figure 1d). On the other hand, amo...
When investigated in a model cell system, these lengthened UTR conferred reduced transcript stability and, for one of these isoforms, short uORFs introduced by the added length altered protein expression kinetics. This study highlights instances in which current reference databases are incomplete ...
Will create exons.bed, 3UTR.bed, 5UTR.bed, genes.bed, cds.bed in Example Download GFF/GTF(GRCh37, v25, comprehensive, CHR) from gencodegenes.org: wget ftp://ftp.sanger.ac.uk/pub/gencode/Gencode_human/release_25/gencode.v25.annotation.gff3.gz \ && gunzip gencode.v25.annotation...
A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation. Genes Dev. 29, 2037–2053 (2015). Article CAS PubMed PubMed Central Google Scholar Download references Acknowledgements The authors apologize to those researchers whose work was not cited owing ...