5-HydroxyisouratePeriplasmTLPThe primary, secondary, tertiary and quaternary structures of TTRs have been highly conserved during the evolution of vertebrates. This suggests that the TTR gene must have evolved prior to the divergence of vertebrates from invertebrates. Open reading frames predicted to ...
2011. Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae . Acta Crystallogr. D 67 :671–677... JB French,SE Ealick - 《Acta Crystallographica》 被引量: 20发表: 2011年 加载更多0
5-Hydroxyisourate hydrolase (HIUase) is an enzyme widely distributed in prokaryotic and eukaryotic organisms that catalyzes the hydrolysis of HIU into OHCU in the degradation route from urate to (S)-allantoin. During early vertebrate evolution, a duplication event in the gene encoding HIUase gave...
Tweaking the Structure to Radically Change the Function: The Evolution of Transthyretin from 5-Hydroxyisourate Hydrolase to Triiodothyronine Distributor to Thyroxine Distributordoi:10.3389/fendo.2014.00245Samantha Richardson
Hydroxyisourate hydrolasesFunctional trade-offEvolutionTransthyretin (TTR), a plasma thyroid hormone distributor protein (THDP), emerged from 5-hydroxyisourate hydrolase (HIUHase), an enzyme involved in urate metabolism, by gene duplication at a stage of chordate evolution. Comparison of amino acid ...