5-Hydroxyisourate hydrolase (HIUase) is an enzyme widely distributed in prokaryotic and eukaryotic organisms that catalyzes the hydrolysis of HIU into OHCU in the degradation route from urate to (S)-allantoin. During early vertebrate evolution, a duplication event in the gene encoding HIUase gave...
5-Hydroxyisourate.svg(SVG檔案,表面大小: 1,002 × 742 像素,檔案大小:5 KB) 文件來源:維基百科-File:5-Hydroxyisourate.svg 檔案歷史 點擊日期/時間以檢視當時出現過的檔案。 日期/時間縮圖維度用戶註解 目前2014年8月5日 (二) 17:09 1,002×742(5 KB)行医(對話|貢獻)(文件来源:[http://zh.wi...
The HpxO enzyme from Klebsiella pneumoniae was recently proposed, on the basis of genetic studies, to catalyze the hydroxylation of uric acid to 5-hydroxyisourate as part of the purine catabolic pathway. Its primary sequence suggests tha... SE O'Leary,KA Hicks,SE Ealick,... - 《Biochemistr...
5-HydroxyisouratePeriplasmTLPThe primary, secondary, tertiary and quaternary structures of TTRs have been highly conserved during the evolution of vertebrates. This suggests that the TTR gene must have evolved prior to the divergence of vertebrates from invertebrates. Open reading frames predicted to ...
Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae . Acta Crystallogr. 2011; D67 :671–677.French JB, Ealick SE.. Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae . Acta Crystallogr ...
Characterization of Oncorhynchus mykiss 5-hydroxyisourate hydrolase/transthyretin superfamily: evolutionary and func- tional analyses. Gene (2013) 531:326-36. doi:10.1016/j.gene.2013.08.071Kasai K, Nishiyama N, Yamauchi K.. Characterization of Oncorhynchus mykiss 5-hydroxyisourate hydrolase/transthyretin...
The crystal structure of the transthyretin-like protein from Salmonella dub- lin, a prokaryote 5-hydroxyisourate hydrolase. J Mol Biol 2006; 359: 1389-1399.Hennebry SC, Law RHP, Richardson SJ, Buckle AM & Whisstock JC (2006b) The crystal structure of the transthyretin-like protein from ...
文件:5-Hydroxyisourate.svg 文件 文件历史 文件链接 5-Hydroxyisourate.svg(SVG文件,名义大小:1,002×742像素,文件大小:5 KB) 文件来源:维基百科-File:5-Hydroxyisourate.svg 文件历史 点击日期/时间以查看当时出现过的文件。 日期/时间缩图维度用户注解...
Tweaking the Structure to Radically Change the Function: The Evolution of Transthyretin from 5-Hydroxyisourate Hydrolase to Triiodothyronine Distributor to Thyroxine Distributordoi:10.3389/fendo.2014.00245Samantha Richardson
Transthyretin (TTR), a plasma thyroid hormone distributor protein (THDP), emerged from 5-hydroxyisourate hydrolase (HIUHase), an enzyme involved in urate metabolism, by gene duplication at a stage of...doi:10.1007/s00239-018-9858-4Yamauchi Kiyoshi...