5-HydroxyisouratePeriplasmTLPThe primary, secondary, tertiary and quaternary structures of TTRs have been highly conserved during the evolution of vertebrates. This suggests that the TTR gene must have evolved prior to the divergence of vertebrates from invertebrates. Open reading frames predicted to ...
文件:5-Hydroxyisourate.svg 文件 文件历史 文件链接 5-Hydroxyisourate.svg(SVG文件,名义大小:1,002×742像素,文件大小:5 KB) 文件来源:维基百科-File:5-Hydroxyisourate.svg 文件历史 点击日期/时间以查看当时出现过的文件。 日期/时间缩图维度用户注解...
5-Hydroxyisourate hydrolase (HIUase) is an enzyme widely distributed in prokaryotic and eukaryotic organisms that catalyzes the hydrolysis of HIU into OHCU in the degradation route from urate to (S)-allantoin. During early vertebrate evolution, a duplication event in the gene encoding HIUase gave...
Here, we provide evidence that PucM, a transthyretin-related protein, functions to facilitate the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Based on these results, we propose that transthyretin-related proteins present in diverse organisms are not functionally related...
Tweaking the Structure to Radically Change the Function: The Evolution of Transthyretin from 5-Hydroxyisourate Hydrolase to Triiodothyronine Distributor to Thyroxine Distributordoi:10.3389/fendo.2014.00245Samantha Richardson
Transthyretin (TTR), a plasma thyroid hormone distributor protein (THDP), emerged from 5-hydroxyisourate hydrolase (HIUHase), an enzyme involved in urate metabolism, by gene duplication at a stage of...doi:10.1007/s00239-018-9858-4Yamauchi Kiyoshi...