根据世界卫生组织估计,全球现有抑郁症患者约1.21亿。 References: 1. Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene , Science|Story| 送TA礼物 回复 1楼2006-09-09 13:36 笔之笔 高级粉丝 3 新陈代谢中濒死细胞最后的“秘密” 濒死细胞作出吃我的标记,...
Stress, the 5-HTT Gene and DepressionMedina, JohnPsychiatric Times
[3]Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, McClay J, Mill J, Martin J, Braithwaite A, Poulton R. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389. 作者:Sebastian Ocklenburg, Ph.D. ...
Conclusion 5 HTT LPR L/L geno type may be a protective factor for abnormal hilit.No corelation was found between polym orphisms of 5 HTT gene and patients with abnormal hilit. Keywords: abnormal hilit / abnormal black savda / genetic polymorphisms / 5 HTT / 5 HTTVN TR ...
The L-allelic variant of the 5-HTT gene promoter is associated with 5- HTT overexpression. This higher expression of the transporter leads to higher uptake of serotonin, resulting in activation of mitogenic pathways thereby inducing smooth muscle hyperplasia. The study focuses on the possible ...
上海交通大学医学院18SS39S博士学位论文题目:强迫症症状维度及5-HTT基因、TPH2基因多态性研究指导教师:**泽萍教授指导小组成员:谢斌教授何燕玲教授张海音教授研究生:李樱培养单位:上海交通大学医学院附属精神卫生中心关键词:强迫症耶鲁.布朗强迫症状维度量表症状维度5-HTT基因TPH2基因资助基金:上海市科学技术委员会基金项...
5-HTTLPR基因的官方名字为 SLC6A4 溶质携带家族6（神经递质转运蛋白，羟色胺）成员4 SLC6A4 Official Symbol: SLC6A4 and Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 [Homo sapiens]Other Aliases: 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, hSERT Ot...
5-HTTLPR 5-HTTgene.1inkedpolymorphicRegion 5一羟色胺转运体基因启动子区 SSRIs Selectiveserotoninreuptake inhibitors 选择性5一HT再摄取抑制剂 HAMD Hamilton rating scalefor depression 汉密尔顿抑郁量表 HAMA Hamilton rating scalefor anxiety 汉密尔顿焦虑量表 ...
ObjectiveTo study the correlation between 5- serotonin transporter (5-HTT) gene polymorphism and the first episode major depressive disorder(MDD) and cognitive function in adolescent. Methods5-HTT genotype and allele were detected by polymerase chain reaction (PCR) amplification of 76 patients with fi...
该基因位于17q11.1-12,编码5-HTT蛋白。现已发现该基因存在两个常见的多态性位点,即转录起始点上游大约1Kb处启动子区有一个44bp片段插入/缺失的长度多态性(5-HTT,gene-linkedpolymorphicregin,5-HTTLPR;L,s);第2含子内存在一个可变数目串联重复序列(5-HTT-VNTR),包括16-17个碱基的9/10/12个拷贝数的三种...