Stress, the 5-HTT Gene and DepressionMedina, JohnPsychiatric Times
(2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 386-389. 作者:Sebastian Ocklenburg, Ph.D.翻译:唐诗来源:Psychology Today《The Serotonin Transporter Gene and Depression》免责声明:文章内容为作者个人观点,不代表本公众号赞同或支持其观点...
(2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301(5631), 386-389. Chiao, J. Y., &Blizinsky, K. D. (2010). Culture-gene coev- olution of individualism-collectivism and the serotonin transporter gene. Proceedings of the Royal ...
Meta·analysisOiltherelationshipbetween5-HTTgenepolymorphismanddepression RENShu—min,LV Shao—ni,LIUChuan—xin,HANXiu—tao,ZHUQi—zhen,TIANYong—xiao.JiningMedicalCollege,Jining272067,Chi— na 【Abstract】 objective Toassesstheassociationsof5-H_rrgenepolymorphismwithdepressionbyMeta— ...
态性(5?mT,gene?linkedpolymorphicregin,5-HTYI~R;L,s);第 2含子内存在一个可变数目串联重复序列(5.H1TI'-VNTR),包 括16.17个碱基的9/10/12个拷贝数的三种片段. 启动子区多态性5-HTI~R,为人类和灵长类所特有,在人 类情绪调节方面有非常重要的作用.它影响转录活性和5. ...
In explorative analyses, the most severe degree of sexual and emotional abuse also yielded significant interaction effects (po0.05). This study revealed interactions between physical abuse and rs1360780 of the FKBP5 gene, confirming its role in the individual susceptibility to depression. Given the ...
BackgroundMajor depression and suicide are associated with fewer serotonin transporter (5-HTT) sites. The 5′-flanking promoter region of the 5-HTT gene
Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide. In this review,
This review addresses the roles that both different gene polymorphisms involved in 5-HT signaling and the different 5-HT receptors (i.e. 5-HT1A, 5-HT1B, 5-HT4, and 5-HT7) may have in the pathophysiology of depression and the antidepressant response. A streamlined knowledge of these 5-...
Several studies have implicated an insertion/deletion polymorphism in the promoter region of the serotonin transporter gene (SLC6A4; 5-HTT) in the development of mood disorders. In the present study of a sample of 247 young adult female twins from Missouri, we examine whether this polymorphism ...