3 Yin, W. et al. Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist.Cell Discov4, 12, doi:10.1038/s41421-018-0009-2 (2018). 4 Xu, P. et al. Structures of the human dopamine D3 receptor-Gi complexes.Mol Cell81, 1147-1159 e1144, doi:10.1016/j...
3 Yin, W. et al. Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist. Cell Discov4, 12, doi:10.1038/s41421-018-0009-2 (2018). 4 Xu, P. et al. Structures of the human dopamine D3 receptor-Gi complexes. Mol Cell81, 1147-1159 e1144, doi:10.1016...
我们期待未来能够更精确地调控5-HT受体的功能,以开发出更高效、更安全的治疗策略,为人们的健康保驾护航。 参考文献: 1.Orlova Y, Rizzoli P, Loder E. Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor ...
近日,贝勒医学院徐勇团队于Science Advances发表文章“Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans”,揭示了5-HT影响记忆的心得神经机制,并发现一种5HT2C受体激动剂,减肥药氯卡色林,可能有助于减轻阿尔茨海默症导致的认知损伤。 图1 HTR2C突变导致小鼠记忆和海马可塑性的...
5-羟色胺(5-HT)又称血清素(serotonin),是一种重要的单胺类神经递质,广泛分布于中枢神经系统和外周组织。中枢神经系统的5-HT参与了进食、睡眠、学习记忆、情绪、社交等多种行为的调节,而外周的5-HT则... 5-羟色胺(5-HT)又称血清素(serotonin),是一种重要的单胺类神经递质,广泛分布于中枢神经系统和外周组...
那5-HT及其受体是如何影响认知与记忆的呢?近日,贝勒医学院徐勇团队于Science Advances发表文章“Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans”,揭示了5-HT影响记忆的心得神经机制,并发现一种5HT2C受体激动剂,减肥药氯卡色林,可能有助于减轻阿尔茨海默症导致的认知损伤。
Serotonin (5-HT) and its receptors have been suggested to play an active role in ss-cell expansion during pregnancy in rodents. 5-HT is produced in ss-cells, stored in insulin granules and thus co-released with insulin upon stimulation. 5-HT receptors belong to a diverse group of G-...
5-羟色胺(5-HT)又称血清素(serotonin),是一种重要的单胺类神经递质,广泛分布于中枢神经系统和外周组织。中枢神经系统的5-HT参与了进食、睡眠、学习记忆、情绪、社交等多种行为的调节,而外周的5-HT则对胃肠蠕动、血管收缩、血小板聚集等生理过程的调控至关重要。
3.Göthert M, Bönisch H, Malinowska B, Schlicker E. Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part II. Some contributions of Manfred Göthert. Pharmacol Rep. 2020 Apr;72(2):271-284. ...
who had exhibited major motor recovery after transplantation with dopamine-rich fetal mesencephalic tissue but had later developed off-medication dyskinesias. The dyskinesias were markedly attenuated by systemic administration of a serotonin [5-hydroxytryptamine (5-HT)] receptor (5-HT1A) agonist, which...