5 alpha-reductase activity in cultured human dermal papilla cells from beard compared with reticular dermal fibroblasts. J Invest Dermatol 1990;94:150-2.Itami S, Kurata S, Takayasu S (1990) 5α-Reductase activity in cultured human dermal papilla cells from beard compared with reticular dermal ...
4) 5α-reductase-2 5α-还原酶-25) steroid 5α-reductatse inhibitors 甾体5α-还原酶 1. And inhibition constant(K_i) of the steroid 5α-reductatse inhibitors could be calculated according to the Linewea. 报道了一种用高效液相色谱法(HPLC)筛选甾体5α-还原酶抑制剂的体外模型。
The present studies examined the effects of basic fibroblast growth factor (bFGF) on 5α-reductase activity of cultured Leydig cells from immature rats. Basic FGF inhibited both hCG- and 8-bromo-cyclic AMP-stimulated 5α-reductase activity in a dose-dependent manner; however, it had little or...
The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concen...
This activity reviews 5-alpha-reductase deficiency, an important cause of ambiguous genitalia in children. Initially, the phenotype of children with 5-alpha-reductase deficiency can vary from underdeveloped male genitalia to fully developed female genitalia. This phenotype may change during puberty, at ...
It is not clear if this increase in 5alpha-reduction during luteal phase is mediated by 5alpha-reductase type 1 or 2 and what are possible triggers for its stimulation. Paradoxically an increase in 5alpha-reductase activity has been reported by our group and others in annovulatory patients wi...
Objectives: To study the changes of sexual gland 5α reductase type Ⅱ activity in pubertal and adult rats with diabetes.Methods: We selected 40 and 90 days old male Wistar rats as pubertal and adult animal model respectively, 30 rats in each group. The rats were randomly divided into three...
raised as girls.At puberty masculinisation develops which is associated with a change in gender identity.The biochemical diagnosis is based on a high T over DHT ratio in blood, on a high etiocholanolone over androsterone ratio in urine and confirmed by a low 5a-reductase activity in genital...
The THF/5 alpha-THF ratios, however, were lower in both the normal children and the affected infants, suggesting increased 5 alpha-reductase activity in infancy. The affected infants had THF/5 alpha-THF ratios comparable to ratios in adult carrier males and significantly lower than ratios in ...
Differential alterations in 5?-reductase type 1 and type 2 levels during development and progression of prostate cancer Finasteride, a 5αR2 inhibitor, was shown to reduce the prevalence of PCa in the Prostate Cancer Prevention Trial. However, inhibition of both 5αR ... Lynn,N.,Thomas,......