Due to the heterogeneity of breast cancer cells, cytotoxic treatments targeting proliferative cancer cells could not eradicate all cancer cells. Compelling evidence suggests that breast cancer stem cells (BCSCs) have a crucial impact in current shortcomings of cancer therapy because they are largely ...
A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line[J]. Biochem Biophy Res Commun, 2004, 321(4):1010-1016.Gao C,Mi Z,Guo H. A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line[J].Biochemical and ...
Enoxacin and its bone-seeking bisphosphonate derivative, bis-enoxacin, have recently captured attention as potential therapeutic agents for the treatment of cancer and bone disease. No differences in growth or survival of 4T1 murine breast cancer cells were detected at a concentration of 50 µ...
Several murine cell lines are used for adipogenesis studies in vitro, such as the 3T3-L1 cell line [23] or immortalized SVF cells [24]. However, the use of a non-immortalized primary SVF cell system using female mice is important for studying the effects of breast cancer on adipocyte ...
Original in vitro and in vivo models were used where 3D-spheroids or cultures of murine 4T1 breast cancer cells were submitted to IH cycles, and nude NMRI mice, orthotopically implanted with 4T1 cells, were submitted to chronic IH exposure before and after implantation. The role of the ...
ACT001 is a novel sesquiterpene lactone derivative with anticancer effects, including the reversal of tamoxifen resistance in estrogen receptor-positive breast cancer cells. However, few studies have investigated the anticancer ...
Wang W, Belosay A, Yang X, Hartman JA, Song H, Iwaniec UT, et al. Effects of letrozole on breast cancer micro-metastatic tumor growth in bone and lung in mice inoculated with murine 4T1 cells. Clin Exp Metastasis 2016;33:475-85....
This study is aim to evaluate the anti-fatigue effects and mechanism of Bu-Zhong-Yi-Qi pill in murine 4 T1 breast cancer mice were treated with paclitaxel. Methods Breast cancer mice established with murine 4 T1 cells were randomly and repectively divided into five groups: negative control ...
4T1 mu- rine mammary carcinoma cells enhance macrophage-medi- ated innate inflammatory responses[J]. PLoS ONE,2015, 10(7):1 037. [27] Rashid OM,Nagahashi M,Ramachandran S,et al. An improved syngeneic orthotopic murine model of human breast cancer progression[J]. Breast Cancer Res Treat, ...
Human tumor cells generally metastasize poorly in mice and when metastasis does occur, unexpected metastatic characteristics are often observed. In contrast, murine tumor cell models often metastasize more effectively and display metastatic characteristics more similar to those observed in cancer patients [...