Bacteria isolated from multiple environments use the synthetic quinolone antibiotics ciprofloxacin, levofloxacin, and nalidixic acid as sole carbon and energy sources.Huse, H.Whiteley, M.Chemical ReviewsHuse H, Whiteley M. 2011. 4-Quinolones: smart phones of the mi- crobial world. Chem. Rev. 111...
Typical N-alkyl-4-quinolone derivatives are drugs such as ciprofloxacin, norfloxacin, and oxolinic acid, which have emerged as potent antibiotics (Figure 1). Traditional synthetic approaches to the 4-quinolone framework are based on cyclocondensation involving Conrad–Limpach [14,15,16,17], ...
New quinolones are very potent compounds against Gram-negative bacteria, including Pseudomonas, and staphylococci. They are particularly interesting because of their oral availability and their pharmacokinetic properties. When combined with other common antibiotics they appear to have mostly indifferent effects...
[ON THE RATIONAL USE OF ANTIBIOTICS IN THE TREATMENT OF INFLAMMATORY DISEASES OF THE BILE DUCTS] The role of microorganisms in the etiology and persistence of chronic wounds remains poorly understood. The chronic wound bed houses a complex microenviron... MS Poliak - 《Vestnik Khirurgii Imeni ...
Antibiotics in the treatment of acute exacerbations of chronic bronchitis. The benefit of antimicrobial therapy for patients with an acute exacerbation of chronic bronchitis (AECB) remains controversial for two main reasons. First... L Lisa,Dever,Kavitha,... - 《Expert Opinion on Investigational Dru...
Virulence properties of pathogenic bacteria, as well as resistance to antibiotics, are thought to arise through a specialization process favoured by the strong selection pressure imposed in clinical treatments. Nevertheless, in the case ... A Alonso,F Rojo,JL Martínez - 《Environmental Microbiology》...
Differential ion mobility spectrometryIon/molecule reactions4-Quinolone antibioticsProtomer separationGas phase ion/molecule reactions are often used in analytical applications to support the analysis of isomers or to identify specific functional groups of organic molecules. Until now, deliberate chemical ...
Ciprofloxacin was found to be the most active of a group of 4-quinolone antibiotics tested against the SA 2 f strain of Chlamydia trachomatis (MBC and MIC 1.0 mg/l). Against genital isolates of Chlamydia trachomatis , ciprofloxacin was twice as active as rosoxacin. Ciprofloxacin showed similar...
Therefore, 20(S)-ginsenoside Rh2 is expected to be used for preparing a synergist of quinolone antibiotics, and can be developed into assistant drugs of anti-infective therapy.王广基孙渊周芳王瑶瑶张经纬查伟斌汪辉郝刚罗丹
Effect of subin- hibitory concentrations of antibiotics on extracellular Shiga-like toxin I. In- fection 1992;20:25-9.Kimmitt PT, Harwood CR, Barer MR. Induction of type 2 Shiga toxin synthesis in Escherichia coli O157 by 4-quinolones. Lancet, 1999, 353(9164):1588-1589....