that are feared to develop in injectable new-quinolone group antibiotics. On the other hand, PZFX shows strong antibacterial strength even against bacteria that show resistance to cephem group, carbapenem group and amino glycoside group antibacterial drugs. An excellent therapeutic effect as compared ...
Quinolone antibiotics are a class of antibiotics that target bacterial type II topoisomerases, such as DNA gyrase and topoisomerase IV, leading to the inhibition of bacterial DNA synthesis. They are known for their broad-spectrum activity against Gram-negative pathogens and are essential in treating ...
1.(Pharmacology) any of a group of synthetic antibiotics, including ciprofloxacin, that inactivate an enzyme required for the replication of certain microorganisms 2.(Pathology) any of a group of synthetic antibiotics, including ciprofloxacin, that inactivate an enzyme required for the replication of ...
PURPOSE OF REVIEW: Quinolones are a group of synthetic antibiotics widely use as first-line treatment for many infections. There has been an increase in the incidence of hypersensitivity reactions to quinolones in recent years, likely due to increased prescription. The purpose of this review is to...
Quinolones are synthetic broad-spectrum antibiotics effective against a wide range of bacteria, including Gram-negative and Gram-positive ones. They are used in livestock and aquaculture treatments. Their base structure is constituted by 2 condensed rings, both containing an N-residue in position 1 ...
Huang D, Okada K, Komori C, Itoi E and Suzuki T: Enhanced antitumor activity of ultrasonic irradiation in the presence of new quinolone antibiotics in vitro. Cancer Sci 95: 845-849, 2004.Enhanced antitumor activity of ultrasonic irradiation in the presence of new quinolone antibiotics in vitro...
Quinolone antibiotics used widely for the treatment of infections induced by E. coli. • Several novel quinolone derivatives exhibited excellent in vitro and in vivo activities against E. coli. • The recent achievements in quinolone derivatives with potential activity against E. coli were summarize...
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. The viral enzyme integrase is essential for the replication of human immunodeficiency virus type 1 (HIV-1) and represents a remaining target for antiretrov... M Sato,T Motomura,H Aramaki,... - 《Journal of Medicinal Chemistry...
Quinolones are synthetic antibiotics with a bicyclic core structure derived from 4-quinolone. They were discovered in the 1960s, as nalidixic acid the first to be discovered (Pham et al., 2019). Later on, fluorination of these compounds lead to the obtention (→ what word do you want to ...
14. A solution of claim 4, where the C1-4 carboxy ester is the ethyl ester. 15. A solution of claim 4 where the C1-4 carboxy ester is the methyl ester. Description: FIELD OF THE INVENTION This invention is related to the field of quinolone antibiotics and involves the use of Mg2+...