4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL), encoded by, is an orphan paralogue of 4-hydroxyphenylpyruvate dioxygenase (HPD), an iron-dependent dioxygenase involved in tyrosine catabolism. The function and association of HPDL with human diseases remain unknown.We applied exome sequencing ...
英文名称: 4-Hydroxyphenylpyruvate Dioxygenase Human Recombinant 总访问: 310 国产/进口: 进口 半年访问: 19 产地/品牌: prospec 产品类别: 细胞生物学试剂 规格: ENZ-015 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 ...
(1994) A Streptomyces avermitilis gene encoding a 4-hydroxyphenylpyruvic acid dioxygenase-like protein that directs the production of homogentisic acid and an... CD Denoya,DD Skinner,MR Morgenstern - 《Journal of Bacteriology》 被引量: 162发表: 1994年 (4-Hydroxyphenyl)pyruvate dioxygenase from Str...
The human enzyme has a related composition, suggesting that also the eukaryotic form belongs to this protein type, but with a blocked N-terminus like in many other eukaryotic intracellular proteins. Secondary structure predictions suggest an alpha/beta mixed structure, fairly typical of globular ...
4-Hydroxyphenylpyruvate dioxygenase (Hpd, EC 1.13.11.27) catalyzes the conversion of 4-hydroxyphenylpyruvate into homogentisate in the second step of oxidative tyrosine catabolism. This pathway is known from bacteria and eukaryotes, but so far no archaeal Hpd has been described. Here, we report the...
Biallelic variants in HPDL , encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative conditionShereen G. Ghosh MScSangmoon Lee MD, PhDRudy Fabunan MSGuoliang Chai PhDMaha S. Zaki MD, PhDGhada Abdel-Salam PhD...
Various methods and compositions of treating 4-hydroxyphenylpyruvate dioxygenase-like (HPDL)-related diseases or disorders are presented herein. Also presented herein are methods of increasing CoQ10 biosynthesis, and methods of determining whether a subject will benefit from a CoQ10 or CoQ10 ...
Various methods and compositions of treating 4-hydroxyphenylpyruvate dioxygenase-like (HPDL)-r elated diseases or disorders are presented herein. Also presented herein are methods of increasing CoQlO biosynthesis, and methods of determining whether a subject will benefit from a CoQlO or CoQlO ...
(1992) Characterization of 4- hydroxyphenylpyruvatedioxygenase. Primary structure of the Pseudomonas enzyme, Eur. J. Biochem. 205,459-466.Ruetschi, U., Odelhog, B., Lindstedt, S., Barros-Soderling, J., Persson, B., and Jornvall, H. (1992) Characterization of 4- hydroxyphenylpyruvate ...
The primary structure of Pseudomonas 4-hydroxyphenylpyruvate dioxygenase was determined. Sequence degradation of the intact protein and of peptides from three different digests of the carboxymethylated protein established a 357-residue polypeptide chain with a free α-amino group. Hydroxylamine cleavage at...