Lactonisation of the stereoisomeric N-(carboxymethyl)-4-phenyl-4-ethylpyrrolidin-3-ols (10a and b) as well as of the corresponding methyl (9) and ethyl (7) esters and of their 3-acetates (11) afforded the bicyclic lactone, 6-phenyl-6-ethyl-1-aza-4-oxabicyclo[3.2.1]octan-3-one (...
Synthesis of 2-((4-((E)-1-(Hydroxyimino)ethyl)phenyl)amino)-2-oxoethyl Cinnamate (5) To a stirred solution of compound (4) (0.43 mmol) in absolute ethanol (2.90 mL), hydroxylamine hydrochloride (0.69 mmol) and sodium acetate (0.86 mmol) was added. The reaction mixture was stirred at...